In this issue of , McGarvey et al. characterize chromatin accessibility and gene regulation at single-cell resolution in the zebrafish embryo 24 h after fertilization, providing a valuable resource. Their findings add another important piece to understanding the dynamic landscape of gene expression and regulation during early vertebrate development and hint at the dramatic changes single-cell genomics is bringing to the field of developmental biology.
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http://dx.doi.org/10.1016/j.xgen.2021.100087 | DOI Listing |
Diagnostics (Basel)
November 2024
Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Background/objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies).
View Article and Find Full Text PDFMed J Islam Repub Iran
July 2024
Department of Biology, Naghshejahan Higher Education Institute, Isfahan, Iran.
Background: The skin is the biggest organ in the body and has several important functions in protection and regulation. However, wound development can disrupt the natural healing process, leading to challenges such as chronic wounds, persistent infections, and impaired angiogenesis. These issues not only affect individuals' well-being but also pose significant economic burdens on healthcare systems.
View Article and Find Full Text PDFClin Cosmet Investig Dermatol
November 2024
Dermatology Hospital of Southern Medical University, Zhou Guang, People's Republic of China.
Background: Skin cutaneous melanoma (SKCM) ranks among the most prevalent malignant tumors, highlighting the significance of identifying new research targets. In this study, our objective was to pinpoint pivotal genes implicated in SKCM pathogenesis and ascertain their potential as prognostic biomarkers.
Methods: Leveraging data from 1809 normal skin samples and 471 SKCM samples, we identified differentially expressed genes (DEGs).
Heliyon
October 2024
Department of Respiratory and Critical Care Medicine, Southeast University, Zhongda Hospital, Nanjing, 210009, China.
FASEB J
September 2024
College of Animal Science and Technology, Hunan Agricultural University, Changsha, P.R. China.
Pro-inflammatory cytokines in muscle play a pivotal role in physiological responses and in the pathophysiology of inflammatory disease and muscle atrophy. Lactobacillus delbrueckii (LD), as a kind of probiotics, has inhibitory effects on pro-inflammatory cytokines associated with various inflammatory diseases. This study was conducted to explore the effect of dietary LD on the lipopolysaccharide (LPS)-induced muscle inflammation and atrophy in piglets and to elucidate the underlying mechanism.
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