The discovery of regulatory domains has been limited to the investigation of transcription factors and homologous protein sequences. In this issue of , motivated by an oncogenic protein fusion, Tak et al. direct the regulatory potential of a nontraditional effector domain to novel genomic loci with fusions to programmable DNA-binding domains.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903755 | PMC |
| http://dx.doi.org/10.1016/j.xgen.2022.100122 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accelerating discovery of bioactive ligands with pharmacophore-informed generative models.
Nat Commun
March 2025
Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Deep generative models have advanced drug discovery but often generate compounds with limited structural novelty, providing constrained inspiration for medicinal chemists. To address this, we develop TransPharmer, a generative model that integrates ligand-based interpretable pharmacophore fingerprints with a generative pre-training transformer (GPT)-based framework for de novo molecule generation. TransPharmer excels in unconditioned distribution learning, de novo generation, and scaffold elaboration under pharmacophoric constraints.
View Article and Find Full Text PDFIdentifying the Function of Kinesin Superfamily Proteins in Gastric Cancer: Implications for Signal Transduction, Clinical Significance, and Potential Therapeutic Approaches.
Clin Res Hepatol Gastroenterol
March 2025
Department of Allied Science, Graphic Era Hill University, Bhimtal, Uttarakhand, 248002; Graphic Era Deemed to be University, Dehradun, Uttarakhand, India. Electronic address:
Gastric cancer (GC), a leading cause of cancer-related mortality, poses a significant global health challenge. Given its complex etiology, understanding the molecular pathways driving GC progression is crucial for developing innovative therapeutic strategies. Among the diverse proteins involved in cellular transport and mitotic regulation, kinesin superfamily proteins (KIFs) have emerged as key players in tumor biology.
View Article and Find Full Text PDFAcupuncture inhibits epithelial mesenchymal transition in allergic asthma rats by activating the PI3K/AKT pathway through DEK activation.
Zhen Ci Yan Jiu
February 2025
Shanxi Acupuncture Hospital, Taiyuan 030006.
Objectives: To observe the effect of acupuncture at "Dazhui" (GV14) and "Shenzhu" (GV12) on DEK/phosphorylated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and epithelial-mesenchymal transition related factors in rats with allergic asthma (AA), so as to explore its potential mechanism in the treatment of AA.
Methods: Sixty SD rats were randomly divided into normal, model, acupuncture, dexamethasone (DEX) and sham-acupuncture groups, with 12 rats in each group. The AA model was made by intraperitoneal injection of mixture solution of ovalbumin and aluminium hydroxide gel (on day 1 and 7) and followed by inhalation of atomized 1% ovalbumin (30 min, from day 15, once daily for 14 days).
Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs): Emerging strategies for cancer therapy.
Eur J Med Chem
March 2025
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; Institute of Precision Drug Innovation and Cancer Center, Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China. Electronic address:
Cyclin-dependent kinases (CDKs) are pivotal regulators of the cell cycle and transcriptional machinery, making them attractive targets for cancer therapy. While CDK inhibitors have demonstrated promising clinical outcomes, they also face challenges in enhancing efficacy, particularly in overcoming drug resistance. Combination therapies have emerged as a key strategy to augment the effectiveness of CDK inhibitors when used alongside other kinase inhibitors or non-kinase-targeted agents.
View Article and Find Full Text PDFCalnexin promotes glioblastoma progression by inducing protective mitophagy through the MEK/ERK/BNIP3 pathway.
Theranostics
February 2025
Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, 250012 Jinan, China.
Glioblastoma multiforme (GBM), one of the most malignant tumors of the central nervous system, has a poor prognosis, mainly because of its high recurrence caused by the rapid development of drug resistance to postoperative chemotherapy. Although macroautophagy/autophagy is believed to be a fundamental factor in tumor survival during chemotherapy, there is still a lack of autophagy biomarkers for predicting patient prognosis and chemotherapeutic efficacy in clinical practice. We combined transcriptomic and single-cell sequencing data to identify differentially expressed autophagy-related genes in gliomas.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!