The treatment of pressure ulcer is of an extreme clinical and social concern. Effective and thorough debridement lays the foundation for favorable wound healing. Recently, a case report confirmed the efficacy of a combined application of methylene blue staining and ultrasonic debridement for pressure ulcer debridement. A 91-year-old male who suffered from severe pressure ulcers for over 6 years eventually obtained a favorable restoration after receiving surgical debridement optimized with methylene blue staining and ultrasonic debridement. We write to learn more about the details of the case. In this letter, we raised some questions involving the identification capability of methylene blue staining among different tissues, the application of methylene blue staining for various wounds, the arrangement of the debridement liquid, and the management strategy after wound closure. We thank the authors for creating a successful paradigm and hope the discussion can make sense for guiding subsequent clinical practice.
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http://dx.doi.org/10.1177/15347346231156010 | DOI Listing |
Transl Stroke Res
December 2024
Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
Perihematomal edema (PHE) significantly aggravates secondary brain injury in patients with intracerebral hemorrhage (ICH), yet its detailed mechanisms remain elusive. Neutrophil extracellular traps (NETs) are known to exacerbate neurological deficits and worsen outcomes after stroke. This study explores the potential role of NETs in the pathogenesis of brain edema following ICH.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara, 144411, India.
The fabricating of extremely effective, economical, ecologically safe, and reusable nanoparticle (NP) catalysts for the removal of water pollution is urgently needed. This study, spectroscopically optimizes the process parameters for the biogenic synthesis of AgNP catalysts using Cledrdendrum infortunatum leaf extract. The optimization of several synthesis parameters was systematically studied using UV-Vis spectroscopy to identify the ideal conditions for AgNPs formation.
View Article and Find Full Text PDFMed Mycol
December 2024
UR 3738 - CICLY - Equipe Inflammation et immunité de l'épithélium respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France.
Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
Department of Ophthalmology, the First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address:
The increasing prevalence of LED technology heightened blue light (BL) exposure, raising concerns about its long-term effects on ocular health. This study investigated the transcriptomic response of conjunctiva to BL exposure, highlighting potential biomarkers for conjunctival injury. We exposed human conjunctival epithelial cells and C57BL/6 mice to BL to establish in vitro and in vivo models and identified the responsive genes in mice's conjunctiva to BL exposure by RNA sequencing transcriptome analysis.
View Article and Find Full Text PDFPhytomedicine
December 2024
The First Hospital of Hunan University of Chinese Medicine, Hunan, 410007 China. Electronic address:
Unlabelled: Ischemic stroke ranks as the second leading cause of global mortality and disability. Although reperfusion is crucial for salvaging brain tissue, it carries the risk of secondary injuries, such as ferroptosis. Gastrodin, a neuroprotective compound found in Chinese herbal medicine, may regulate this process.
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