AI Article Synopsis
- - Atopic dermatitis (AD) is a long-lasting skin condition caused by environmental triggers, and this study explored the effects of hot water extracts from a specific plant (SHHWE) on AD symptoms in mice.
- - Researchers induced AD in mice using a chemical (DNCB) and tested SHHWE's effectiveness by measuring IgE levels, skin severity, and cytokine signals from immune cells.
- - The findings revealed that SHHWE significantly reduced levels of certain pro-inflammatory cytokines (IL-4, IL-5, IgE) while increasing an anti-inflammatory cytokine (IFN-γ), indicating its potential as a beneficial treatment for AD and its value in cosmetic products.
Article Abstract
Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of (SHHWE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical severity score and cytokine secretions in concanavalin A (Con A)-stimulated splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the pro-inflammatory cytokines that are closely related, were notably suppressed in a does-dependent manner by SHHWE, whereas the level of interferon γ (IFN-γ), the atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was increased. Therefore, these results show that SHHWE has a potent anti-inhibitory effect on AD and is highly valuable for cosmetic development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084757 | PMC |
| http://dx.doi.org/10.4014/jmb.2211.11007 | DOI Listing |
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