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A refined, minimally invasive, reproducible ovine ischaemia-reperfusion-infarction model using implantable defibrillators: Methodology and validation.
Exp Physiol
December 2024
Division of Cardiovascular Science, School of Medical Science, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Ischaemic heart disease remains a leading cause of premature mortality and morbidity. Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising from ischaemic heart disease and the identification of sites for new therapeutic interventions requires a preclinical model that reproduces the key clinical characteristics of myocardial ischaemia, reperfusion and infarction. Here, we describe and validate a refined and minimally invasive translationally relevant approach to induce ischaemia, reperfusion and infarction in the sheep.
View Article and Find Full Text PDFCT-guided Left Stellate Ganglion Cryoneurolysis for Refractory Ventricular Arrhythmias.
Radiology
December 2024
From the Department of Radiology, Division of Interventional Radiology (N.L., N.J.R.), Department of Medicine, Division of Interventional Cardiology (Y.R.), and Department of Medicine, Division of Cardiovascular Medicine (Y.R., G.S., M.G.), UMass Memorial Medical Center and Chan Medical School, 55 Lake Ave N, S2-817A, Worcester, MA 01655; Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image-Guided Medicine, Emory University School of Medicine, Atlanta, Ga (J.K.); Division of Cardiology, Division of Electrophysiology, Emory Heart & Vascular Center at Saint Joseph's Hospital, Atlanta, Ga (A.M.P., C.M.T.); Department of Heart Failure/Transplant Cardiology, Piedmont Heart Institute, Piedmont Healthcare, Atlanta, Ga (D.W.M.); and Franklin College of Arts and Sciences, University of Georgia, Athens, Ga (F.J.P.).
Background Ventricular arrhythmias (VAs), including ventricular tachycardia and ventricular fibrillation, present substantial therapeutic challenges due to their high morbidity, mortality, and increasing prevalence. Current treatments often prove infeasible or inadequate in patients with refractory VAs. Purpose To evaluate the safety and effectiveness of CT-guided left stellate ganglion cryoneurolysis (SGC) in the treatment of refractory VAs.
View Article and Find Full Text PDFEchocardiographic Predictors of Ventricular Arrhythmias in Patients With Left Ventricular Assist Devices and Implantable Cardioverter-Defibrillator.
J Cardiovasc Electrophysiol
December 2024
Department of Cardiology, University Hospital Halle, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.
Aim: To evaluate the predictive value of preoperative echocardiographic parameters for occurrence of VAs in patients with preexisting ICD undergoing LVAD implantation.
Methods And Results: All consecutive patients (n = 264) with previous ICD who underwent LVAD surgery between May 2011 and December 2019 at our institution were included. The patients were predominantly male (89%) with NICM (59%) and a mean age of 59 ± 10 years.
Improved myocardial scar visualization using free-breathing motion-corrected wideband black-blood late gadolinium enhancement imaging in patients with implantable cardiac device.
Diagn Interv Imaging
December 2024
IHU LIRYC, Heart Rhythm Disease Institute, Université de Bordeaux, INSERM U1045, 33604, Pessac, France; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland; Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, 33604 Pessac, France. Electronic address:
Purpose: The purpose of this study was to introduce and evaluate a novel two-dimensional wideband black-blood (BB) LGE sequence, incorporating wideband inversion recovery, wideband T2 preparation, and non-rigid motion correction (MOCO) reconstruction, to improve myocardial scar detection and address artifacts associated with implantable cardioverter defibrillators (ICDs).
Materials And Methods: The wideband MOCO free-breathing BB-LGE sequence was tested on a sheep with ischemic scar and in 22 patients with cardiac disease, including 15 with cardiac implants, at 1.5 T.
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