Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor.

Neoplasia

Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Published: March 2023

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929860PMC
http://dx.doi.org/10.1016/j.neo.2023.100880DOI Listing

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