AI Article Synopsis
- - Biological age can vary greatly among individuals even if they are the same chronological age, leading to the development of distinct aging profiles called 'ageotypes' from multi-omic profiling.
- - Research has revealed new insights into the molecular mechanisms of aging and the potential for nutritional interventions to slow down this process.
- - The brain and nervous system were identified as key areas affected by age-related molecules, with findings suggesting that personalized nutrition and lifestyle adjustments can support healthy aging.
Article Abstract
Undeniably, biological age can significantly differ between individuals of similar chronological age. Longitudinal, deep multi-omic profiling has recently enabled the identification of individuals with distinct aging phenotypes, termed 'ageotypes'. This effort has provided a plethora of data and new insights into the diverse molecular mechanisms presumed to drive aging. Translational opportunities stemming from this knowledge continue to evolve, providing an opportunity for the provision of nutritional interventions aiming to decelerate the aging process. In this framework, the contemporary ageotypes classification was revisited via in silico analyses, with the brain and nervous system being identified as the primary targets of age-related biomolecules, acting through inflammatory and metabolic pathways. Nutritional and lifestyle factors affecting these pathways in the brain and central nervous system that could help guide personalized recommendations for the attainment of healthy aging are discussed.
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| http://dx.doi.org/10.1016/j.maturitas.2023.01.013 | DOI Listing |
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