An apparent redistribution of protein kinase C activity was noted in the particulate and soluble fractions of basal epidermal cells isolated from mice receiving semi-purified diets varying in fat content. An increase in the amount of protein kinase C activity in the particulate fraction and a decrease in the soluble fraction were observed with the mice fed high-fat (24.6% corn oil) diet as compared with those given the low-fat (5% corn oil) diet. Increased levels of phospholipids and an increase in 18:2 and 18:3 side chains of the phospholipids were observed with the high-fat diet.
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