Polymers (Basel)
Departament of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asahi" Technical University of Iasi, Prof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050 Iasi, Romania.
Published: January 2023
Semi-interpenetrating polymer networks (semi-IPN) represent a type of polymeric material that has gained increasing amount of interest for their potential biomedical application. This study presents the synthesis, characterization and tetracycline loading/release capacities of semi-IPNs based on hydroxyethyl methacrylate (HEMA) and poly(4-vinylpyridine) (P4VP) or poly (1-vinyl-4-(1-carboxymethyl) pyridinium betaine) (P4VPB-1) and poly (1-vinyl-4-(2-carboxyethyl) pyridinium betaine) (P4VPB-2). The optimization of the semi-IPNs synthesis was achieved by studying the influence of reaction parameters (chemical structure of the cross-linking agent, HEMA:crosslinker ratio, HEMA:linear polymers ratio and the type of solvent of the linear polymers) on the yield of obtaining semi-IPNs and swelling capacity of these systems. Fourier-transform infrared analysis and scanning electron microscopy highlighted the chemical structures and morphologies of the semi-IPNs. The higher swelling capacity was observed in the case of the PHEMA/P4VPB-2 network due to the increased hydrophilicity of P4VPB-2 compared with P4VP and P4VPB-1 polymers. In vitro release studies of tetracycline reveal that the release mechanism is represented by non-Fickian diffusion being controlled by both diffusion and swelling processes. The antimicrobial activity of semi-IPN-tetracycline systems was tested against and , demonstrating that tetracycline is released from the semi-IPN and retains its bactericidal activity. An increased value of the inhibition zone diameter compared with that of tetracycline indicates the possibility that the semi-IPN containing P4VPB-2 also exhibits intrinsic antimicrobial activity due to the presence of the polybetaine in the network structure.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919840 | PMC |
http://dx.doi.org/10.3390/polym15030490 | DOI Listing |
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