AI Article Synopsis
- Methyl cedryl ether (MCE), derived from cedrol, has potential benefits in preventing obesity and metabolic syndromes by affecting gut microbiota and white adipose tissue (WAT).
- In experiments with male mice, MCE supplementation in a high-fat diet led to significant reductions in body weight, fat cell size, and liver fat accumulation.
- MCE influenced gene expression in WAT, downregulating genes related to fat formation while upregulating those associated with fat burning, and it also improved gut microbiota imbalances linked to obesity.
Article Abstract
Methyl cedryl ether (MCE) is a derivative of cedrol and is widely used as a fragrance compound. The aim of this study was to evaluate the preventative effects of MCE on obesity and related metabolic syndromes and to delineate the mechanisms from the perspective of gut microbiota and white adipose tissues (WAT) transcriptomic profiles. Five-week-old male C57BL/6J mice were randomly assigned into 3 groups and fed with chow diet, high-fat diet (HFD), or HFD supplemented with 0.2% (/) MCE for 13 weeks. We found that MCE significantly reduced body weight, inhibited adipocyte hypertrophy, and ameliorated hepatic steatosis under HFD conditions. MCE dietary supplementation downregulated the expression of adipogenesis genes ( and ) and upregulated the mRNA levels of thermogenesis genes (, , , , , and ) in epididymal WAT. 16S rRNA sequencing revealed that MCE improved gut microbiota dysbiosis in HFD-fed mice, as manifested by the alteration of strains associated with obesity. Further transcriptome analysis of WAT indicated that MCE dramatically changed the gene expression profiles. Our results demonstrate the anti-obesity effect of MCE under HFD conditions, highlighting the nutraceutical potential of MCE for preventing obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9919899 | PMC |
| http://dx.doi.org/10.3390/nu15030788 | DOI Listing |
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