AI Article Synopsis
- Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are two important omega-3 fatty acids found in fish oil, known for their health benefits and safety as dietary supplements.
- Research indicates that these polyunsaturated fatty acids may help counteract neurodegenerative diseases linked to specific amyloid proteins, including those associated with Alzheimer's and Parkinson's diseases.
- The study reveals that EPA and DHA can stabilize the transthyretin (TTR) tetramer by binding to its thyroxin-binding pockets, potentially aiding in the prevention of associated amyloidosis.
Article Abstract
Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and contribute to guaranteeing human health. Studies report that PUFAs have a role in contrasting neurodegenerative processes related to amyloidogenic proteins, such as β-amyloid for AD, α-synuclein in PD, and transthyretin (TTR) in TTR amyloidosis. In this context, we investigated if EPA and DHA can interact directly with TTR, binding inside the thyroxin-binding pockets (TBP) that contribute to the tetramer stabilization. The data obtained showed that EPA and DHA can contribute to stabilizing the TTR tetramer through interactions with TBP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921273 | PMC |
| http://dx.doi.org/10.3390/nu15030749 | DOI Listing |
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