AI Article Synopsis
- Ulcerative colitis (UC) is an inflammatory bowel disease that needs new treatments with better effectiveness and less toxicity, and researchers have focused on a specific polysaccharide called HEP10 isolated from mushrooms.
- HEP10 demonstrated the ability to reduce inflammatory markers and inhibit pathways associated with inflammation in both lab cells and animal models of UC.
- Additionally, HEP10 positively influenced gut microbiota composition, suggesting it could serve as a beneficial dietary supplement for improving conditions like colitis.
Article Abstract
Ulcerative colitis (UC), one of the typical inflammatory bowel diseases caused by dysregulated immunity, still requires novel therapeutic medicine with high efficacy and low toxicity. has been widely used to treat different health problems especially gastrointestinal sickness in China for thousands of years. Here, we isolated, purified, and characterized a novel low weight polysaccharide (HEP10, Mw: 9.9 kDa) from the mycelia of in submerged culture. We explored the therapeutic effect of HEP10 on UC and explored its underlying mechanisms. On one hand, HEP10 suppressed the production of TNF-α, IL-1β, IL-6, inducible iNOS, and COX-2 in LPS challenged murine macrophage RAW264.7 cells, as well as in colons from DSS-induced colitis mice. On the other hand, HEP10 treatment markedly suppressed the activation of NLRP3 inflammasome, NF-κB, AKT, and MAPK pathways. Moreover, HEP10 reversed DSS-induced alternation of the gut community composition and structure by significantly increasing and also promoting functional shifts in gut microbiota. Structural equation modeling also highlighted that HEP10 can change widely through gut microbiota. In conclusion, HEP10 has a better prebiotic effect than the crude polysaccharides of , which can be used as a novel dietary supplement and prebiotic to ameliorate colitis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920828 | PMC |
| http://dx.doi.org/10.3390/nu15030739 | DOI Listing |
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