AI Article Synopsis
- A novel type of silver nanoparticles (AgNPs) measuring 24 nm was synthesized, showing good stability and a narrow size distribution through various analysis techniques like SEM and DLS.
- The AgNPs were combined with a nontoxic hydrogel under specific conditions, and thermal analyses indicated there are no significant interactions between the AgNPs and the hydrogel fibers.
- Both the AgNPs and the AgNPs-hydrogel composites demonstrated low biological activity against a range of living cells and could be useful as drug delivery systems in therapeutic applications.
Article Abstract
A new type of silver nanoparticles (AgNPs) was prepared and comprehensively studied. Scanning electron microscopy (SEM) and dynamic light scattering (DLS) analyses indicated that 24 nm AgNPs with narrow size distribution were obtained while Z-potential confirms their good stability. The composites of the obtained AgNPs with nontoxic-nature-inspired hydrogel were formed upon cooling of the aqueous solution AgNPs and CAla. The thermal gravimetric analysis (TGA) and the differential scanning calorimetry (DSC) do not show significant shifts in the characteristic temperature peaks for pure and silver-enriched gels, which indicates that AgNPs do not strongly interact with CAla fibers, which was also confirmed by SEM. Both AgNPs alone and in the assembly with the gelator CAla were almost biologically passive against bacteria, fungus, cancer, and nontumor human cells, as well as zebra-fish embryos. These studies proved that the new inactive AgNPs-doped hydrogels have potential for the application in therapy as drug delivery media.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922004 | PMC |
| http://dx.doi.org/10.3390/molecules28031194 | DOI Listing |
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