Dry grape peel powder was extracted by three different techniques, stirred tank reactor, Soxhlet and ultrasound extraction. The composition, physical and chemical structure and inherent stability of the extracts were characterized by various methods. The extracts and reference compounds were added to polyethylene and their stabilization efficiency was determined in multiple extrusion experiments. The composition of the extracts was quite similar. Ten main compounds were identified in the extracts, which contained a considerable number of polyphenols, but only small amounts of quercetin and -resveratrol. The extracts proved to be more efficient processing stabilizers than -resveratrol and the commercial stabilizer, Irganox 1010, irrespective of the extraction technology used. In spite of their good processing stabilization effect, polymers containing the extracts had poor residual stability. The differences in processing and long-term stabilization must be related to the different structures of the polyphenols contained by the extracts and the reference compounds. The results clearly prove that the IC50 value determined by the DPPH assay is not suitable for the estimation of the efficiency of a compound as a stabilizer for polymers.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918917 | PMC |
http://dx.doi.org/10.3390/molecules28031011 | DOI Listing |
Front Immunol
January 2025
The Lautenberg Center for Immunology and Cancer Research, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Alternative splicing (AS) is a mechanism that generates translational diversity within a genome. Equally important is the dynamic adaptability of the splicing machinery, which can give preference to one isoform over others encoded by a single gene. These isoform preferences change in response to the cell's state and function.
View Article and Find Full Text PDFObjectives: The pairing of immunotherapy and radiotherapy in the treatment of locally advanced nonsmall cell lung cancer (NSCLC) has shown promise. By combining radiotherapy with immunotherapy, the synergistic effects of these modalities not only bolster antitumor efficacy but also exacerbate lung injury. Consequently, developing a model capable of accurately predicting radiotherapy- and immunotherapy-related pneumonitis in lung cancer patients is a pressing need.
View Article and Find Full Text PDFFront Public Health
January 2025
Outpatient Department, The Second Affiliated Hospital of Air Force Military Medical University, Xi'an, China.
Background: Ethical leadership is crucial in nursing management, and self-compassion is increasingly recognized as a significant factor influencing nurses' job performance. Although the link between ethical leadership and nurse job performance has been established, the specific mechanisms that underlie this relationship remain unclear. Additionally, there is a paucity of research examining the potential role of self-compassion in this context.
View Article and Find Full Text PDFFront Public Health
January 2025
College of Education, Guangzhou University, Guangzhou, Guangdong, China.
Purpose: The occupational well-being of early childhood teachers, as a crucial measure of the stability of the early childhood workforce, is increasingly becoming a core topic of interest within the education system. Work-related stressors, particularly work-family conflict, have drawn significant attention for their impact on the occupational well-being of early childhood teachers, becoming a prominent issue in the education field. However, current research rarely explores the relationship between these factors and the underlying mechanisms involved.
View Article and Find Full Text PDFTher Adv Neurol Disord
January 2025
Department of Neurology, Ulm University, Ulm, Germany.
The advent of antisense oligonucleotide (ASO) therapies in neurodegenerative disorders is associated with enormous hope. Nusinersen treatment was a breakthrough intervention in the recessive disease spinal muscular atrophy, and superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS) seems to be the paradigm disease in dominant degenerative diseases. The results of treatment with the ASO tofersen in SOD1-ALS show that the drug has a convincing beneficial effect on ALS caused by SOD1 mutations, that preclinical studies in rodents predicted the therapeutic effect in the human disease, and that clinical efficacy is associated with a specific sequence of effects of the drug on mechanistic and degenerative biomarkers and, subsequently, functional outcomes such as weight stabilization and ALSFRS-R.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!