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MicroRNA and Messenger RNA Expression Profiles in Canine Mammary Gland Tumor. | LitMetric

MicroRNA and Messenger RNA Expression Profiles in Canine Mammary Gland Tumor.

Int J Mol Sci

Department of Biomedical Laboratory Science, School of Healthcare Science, Eulji University, Uijeongbu 11759, Republic of Korea.

Published: January 2023

AI Article Synopsis

Article Abstract

Canine mammary gland tumor (CMT) is the most frequently diagnosed neoplasm in intact female dogs. As prognosis depends on the malignancy of tumors and metastasis levels, early and accurate diagnosis are crucial for prolongation of life expectancy. The genetic similarity of dogs with humans in addition to environmental and physiological similarities make them ideal models for the study of cancer. In this study, we analyzed differentially expressed microRNAs followed by RNA-Seq to investigate the alterations in mRNA levels based on the malignancy (benign, malignant) and the biopsy locations (tumors, surrounding normal tissues). We identified multiple breast cancer-related genes regardless of malignancy. We found cfa-miR-503 to be the only miRNA that showed altered expression in response to malignancy in CMTs. Although further validation is needed, cfa-miR-503 could be used as a potential diagnostic biomarker as well as a potential RNA-based anti-tumor drug in malignant CMTs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917093PMC
http://dx.doi.org/10.3390/ijms24032618DOI Listing

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