Uncontrolled external bleeding is a common cause of preventable death, and due to the environment in which these events often occur, e.g., in hostile environments, the state security forces are usually the first responders, and in many cases, if they are injured their partners provide the initial assistance. The tourniquet is a fast, effective, and easy-to-learn intervention, although there is a knowledge gap concerning training techniques. The objective is to evaluate the effectiveness of a bleeding control training program on a high-fidelity mannequin in a simulated critical situation in a law enforcement training environment. A quasi-experimental study was carried out with 27 members of the state security forces. They underwent brief theoretical-practical training and were evaluated via a scenario involving a critically ill patient in a hostile environment. The results showed that no member of the state security forces completed all the tourniquet placement steps, 26 (96%) prepared the tourniquet correctly, 21 (77.8%) placed it on the leg, and all the participants adjusted the band to the thickness of the injured limb and secured the windlass to the triangular flange of the device. However, only 23 (85.2%) of the participants placed it effectively. The participants, who were members of the state security forces, were able to effectively resolve a critical situation with active bleeding in a simulation scenario with a high-fidelity mannequin after completing theoretical-practical training.
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http://dx.doi.org/10.3390/ijerph20032494 | DOI Listing |
Pharmaceutics
December 2024
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Etrasimod is a newly FDA-approved Sphingosine-1-Phosphate modulator indicated for moderate and severe ulcerative colitis. It is extensively metabolized in the liver via the cytochrome P450 system and may accumulate markedly in patients with hepatic dysfunction, exposing them to toxicity. The aim of the current study is to utilize a physiologically-based pharmacokinetic modeling approach to evaluate the impact of hepatic impairment on the pharmacokinetic behavior of etrasimod and to appropriately select dosage regimens for patients with chronic liver disease; Methods: PK-Sim was used to develop the etrasimod PBPK model, which was verified using clinical data from healthy subjects and subsequently adapted to reflect the physiological changes associated with varying degrees of hepatic dysfunction; Results: Simulations indicated that hepatic clearance of etrasimod is clearly reduced in patients with Child-Pugh B and C liver impairment.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Chair of Modelling in Engineering Sciences and Medicine, Faculty of Mechanical Engineering, University of Ljubljana, Aškerčeva c. 6, 1000 Ljubljana, Slovenia.
Bolt connections are widely used in construction and engineering to securely join structural elements. These connections are essential for distributing loads across components and ensuring that structures can withstand external forces. The planned failure of these bolts is of great importance in steel safety barriers (SSBs), as it can directly influence the height of the guardrail and the working width of the SSB during the vehicle impact, which consequently affects the crash consequences.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
Department of Mechanical Engineering, University of Michigan-Dearborn, Dearborn, MI 48128, USA.
Cerclage is an orthopedic surgical fixation technique using a cable wrapped, tensioned, and secured around a bone's circumference. It is important to minimize the loss in cable tension that often occurs due to stress relaxation. The purpose of this work was to study the effect of tensioning protocols on the long-term loss of tension due to stress relaxation.
View Article and Find Full Text PDFGenes (Basel)
November 2024
Institute of Forensic Science, Fudan University, Shanghai 200032, China.
Background/objectives: Short tandem repeat (STR) loci are widely used in forensic genetics for identification and kinship analysis. Traditionally, these loci were selected to avoid medical associations, but recent studies suggest that loci such as TH01 and D16S539 may be linked to psychiatric conditions like schizophrenia. This study explores these potential associations and considers the privacy implications related to disease susceptibility.
View Article and Find Full Text PDFAnimals (Basel)
December 2024
Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Meat quality is a complex trait that exhibits significant variation across pig breeds, and the regulatory mechanisms governing pork meat quality are not fully elucidated. We compared the transcriptomics and metabolomics of the longissimus dorsi (LD) muscle between the Songliao Black Pig (SBP) and Large White × Landrace Pig (LWLDP) to investigate breed-specific differences in meat quality and underlying regulatory pathways. The results showed that SBP meat had a higher marbling score and backfat thickness, a richer color, a lower shear force, and reduced drip loss.
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