AI Article Synopsis
- PET/CT techniques are increasingly preferred over traditional scintigraphic methods due to their enhanced sensitivity and ability to accurately quantify activity.
- The study aimed to develop a PET tracer using [Ga]gallium-oxine-labeled heat-damaged red blood cells for improved splenic imaging in patients with ambiguous findings.
- The results from ten patients indicated that the tracer reliably distinguished between splenic and non-splenic lesions, successfully identifying malignant tumors and diagnosing splenic abnormalities.
Article Abstract
Several scintigraphic techniques have been supplemented or replaced by PET/CT methods because of their superior sensitivity, high resolution, and absolute activity quantification capability. The purpose of this project was the development of a PET tracer for splenic imaging, its radiopharmaceutical validation, and its application in selected patients in whom unclear constellations of findings could not be resolved with established imaging methods. Heat-damaged red blood cells (RBCs) were labeled with [Ga]gallium-oxine, which was produced from [Ga]gallium and 8-Hydroxyquinoline (oxine) on an automated synthesizer. Ten patients underwent [Ga]gallium-oxine-RBC-PET/CT for the classification of eleven unclear lesions (3 intra-, 8 extrapancreatic). [Ga]gallium-oxine and [68Ga]gallium-oxine-labeled RBCs could be synthesized reproducibly and reliably. The products met GMP quality standards. The tracer showed high accumulation in splenic tissue. Of the 11 lesions evaluated by PET/CT, 3 were correctly classified as non-splenic, 6 as splenic, 1 as equivocal, and 1 lesion as a splenic hypoplasia. All lesions classified as non-splenic were malignant, and all lesions classified as splenic did not show malignant features during follow-up. PET/CT imaging of the spleen with [Ga]gallium-oxine-labeled, heat-damaged RBCs is feasible and allowed differentiation of splenic from non-splenic tissues, and the diagnosis of splenic anomalies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913950 | PMC |
| http://dx.doi.org/10.3390/diagnostics13030566 | DOI Listing |
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Article Synopsis
- PET/CT techniques are increasingly preferred over traditional scintigraphic methods due to their enhanced sensitivity and ability to accurately quantify activity.
- The study aimed to develop a PET tracer using [Ga]gallium-oxine-labeled heat-damaged red blood cells for improved splenic imaging in patients with ambiguous findings.
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December 2022
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