AI Article Synopsis
- LC-OCT is a new noninvasive imaging technique that improves the diagnosis of skin cancers, particularly basal cell carcinomas (BCCs) compared to traditional dermoscopy.
- A study involving 243 skin lesions showed a significant increase in specificity for LC-OCT (87%) versus dermoscopy (73%), while sensitivity remained consistent at 95% for both methods.
- The findings suggest that LC-OCT could be integrated into the diagnostic process after dermoscopy, potentially reducing unnecessary biopsies for benign lesions without compromising accuracy.
Article Abstract
Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase ( = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64-0.81) to LC-OCT (0.87, CI 0.79-0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89-0.98 for dermoscopy and 0.95 CI 0.90-0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914674 | PMC |
| http://dx.doi.org/10.3390/diagnostics13030361 | DOI Listing |
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