AI Article Synopsis
- Over the past 30 years, research on how cells respond to ionizing radiation (IR) has significantly expanded, particularly focusing on the p38 MAPK signaling pathway.
- p38 MAPK is activated by IR and is involved in crucial cellular processes like cell cycle regulation, apoptosis, and senescence, but its exact role in determining radioresistance or sensitivity remains unclear.
- This review aims to summarize what we know about the p38 MAPK family in the context of IR, including their involvement in REDOX control, fibrosis, and the potential to enhance radiotherapy effects through specific compounds.
Article Abstract
Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways affected by IR, p38 MAPK has been shown to be activated both in vitro and in vivo, with involvement in key processes triggered by IR-mediated genotoxic insult, such as the cell cycle, apoptosis or senescence. However, we do not yet have a definitive clue about the role of p38 MAPK in terms of radioresistance/sensitivity and its potential use to improve current radiotherapy. In this review, we summarize the current knowledge on this family of MAPKs in response to IR as well as in different aspects related to radiotherapy, such as their role in the control of REDOX, fibrosis, and in the radiosensitizing effect of several compounds.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913882 | PMC |
| http://dx.doi.org/10.3390/cancers15030861 | DOI Listing |
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