AI Article Synopsis
- The study aimed to identify risk factors for re-recurrences and disease-specific mortality (DSM) in patients with recurrent thyroid cancer who had surgery between 2000 and 2019.
- Patients with one recurrence and those with multiple re-recurrences were compared on their clinicopathological characteristics and long-term outcomes, revealing a significantly higher DSM in those with re-recurrences (6.8% vs. 0.5%).
- Key findings indicated that older age (≥55), male sex, and a lymph node ratio (LNR) of 0.15 or higher were independent risk factors for re-recurrences, while surgical treatment at the first recurrence was found to be the most effective intervention.
Article Abstract
The purpose of this study was to establish the risk factors for re-recurrences and disease-specific mortality (DSM) in recurrent thyroid cancer. Patients with recurrent thyroid cancer who underwent initial thyroid surgery from January 2000 to December 2019 at Seoul St. Mary's Hospital (Seoul, Korea) were assessed. Clinicopathological characteristics and long-term oncologic outcomes were compared between patients with one recurrence ( = 202) and patients with re-recurrences ( = 44). Logistic regression and cox-regression analyses were conducted to determine the risk factors for re-recurrences and DSM, respectively. Receiver-operating characteristic curve analysis was performed to determine the cutoff value for lymph node ratio (LNR) as a predictor of re-recurrences. DSM was significantly higher in the re-recurrence group compared with the single-recurrence group (6.8% vs. 0.5%, = 0.019). Surgical treatment at the first recurrence significantly lowered the risk of re-recurrences. Age (≥55), male sex, and LNR (≥0.15) were independent significant risk factors for re-recurrences in patients who underwent surgery at the first recurrence. Surgical resection is the optimal treatment for initial thyroid cancer recurrence. LNR at re-operation is more effective in predicting re-recurrence than the absolute number of metastatic LNs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913116 | PMC |
| http://dx.doi.org/10.3390/cancers15030624 | DOI Listing |
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