Objective: To analyze the gene polymorphisms of patients with lymphoma-associated hemophagocytic syndrome in Longyan area, Fujian province.
Methods: A total of 125 patients with lymphoma-associated hemophagocytic syndrome in Longyan, Fujian province, admitted to Longyan First Hospital from May 2017 to November 2020 were selected. Peripheral venous blood was collected from all the patients, and the genotypes of perforin 1 () and interleukin-10 () gene loci were detected by PCR-fluorescence probe method, and the correlation between and gene polymorphisms and lymphoma-associated hemophagocytic syndrome was analyzed.
Results: The mutation frequencies of gene loci rs885821 (C>T), rs885822 (C>T), rs1889490 (G>A) in patients with lymphoma-associated hemophagocytic syndrome were 10.40%, 78.8% and 64.4%, respectively. The mutation frequencies of rs1800872 (A>C), rs1800871 (C>T) and rs1800896 (G>A) of loci were 56.0%, 45.2% and 77.6%, respectively.
Conclusion: and gene loci were polymorphic in patients with lymphoma-associated hemophagocytic syndrome in Longyan area, Fujian province. Alleles C and G of and were risk factors, and alleles T and A were protective factors.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2023.01.016 | DOI Listing |
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