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The correlation between blastocyst morphological parameters and chromosomal euploidy, aneuploidy and other chromosomal abnormalities following pre-implantation genetic testing-a single center retrospective study.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, McGill University, 845 Rue Sherbrooke, O, Montreal, QC, 3HA 0G4, Canada.
Purpose: To examine the association between blastocyst morphology and chromosomal status utilizing pre-implantation genetic testing for aneuploidy (PGT-A).
Methods: A single-center retrospective cohort study including 169 in-vitro fertilization cycles that underwent PGT-A using Next Generation Sequencing (2017-2022). Blastocysts were morphologically scored based on Gardner and Schoolcraft's criteria.
An NGS approach for the identification of precise homoeologous recombination sites between A and C genomes in genus.
Breed Sci
September 2024
Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan.
The introgression of heterologous genomes through interspecific hybridization offers a great opportunity to expand the gene pool of crops, thereby broadening the traits that can be targeted for improvement. The introgression of C genomic regions carrying desirable traits from (AACC) into the diploid (AA) via homoeologous recombination (HR) has been commonly used. However, the precise identification of HR sites remains a significant challenge, limiting the practical application of genome introgression via HR in breeding programs.
View Article and Find Full Text PDFThe Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage.
Medicina (Kaunas)
December 2024
Department of Internal Medicine, Division of Endocrinology, University Hospital Centre Zagreb, Croatian Referral Center for Obesity Treatment, Kišpatićeva 12, 10000 Zagreb, Croatia.
The prevalence of metabolic syndrome (MetS) worldwide is rapid and significant on a global scale. A 2022 meta-analysis of data from 28 million individuals revealed a global prevalence of 45.1%, with notably higher rates in the Eastern Mediterranean Region and the Americas, particularly in high-income countries.
View Article and Find Full Text PDFEnhanced K-storage kinetics for N-doped carbon via controllable dedoping strategy.
Chemistry
January 2025
Nanjing University of Aeronautics and Astronautics, School of Materials Science and Engineering, 29 Yudao St., 210016, Nanjing, CHINA.
As a potential alternative to next-generation LIBs, carbonous materials have garnered significant attention as anode materials for potassium-ion batteries due to their low cost and environmental friendliness. However, carbonaceous materials cannot fulfill the demand of anode for PIBs, due to volume expansion and poor stability during charging/discharging process. It is well-known that N doping can provide active sites for K-storage, and expand the layer distance between graphite layers.
View Article and Find Full Text PDFAdvances in cancer genomics and precision oncology.
Genes Genomics
January 2025
Department of Smart Farm and Agricultural Industry, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Background: Next-generation sequencing has revolutionized genome science over the last two decades. Indeed, the wealth of sequence information on our genome has deepened our understanding on cancer. Cancer is a genetic disease caused by genetic or epigenetic alternations that affect the expression of genes that control cell functions, particularly cell growth and division.
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