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Rho GTPase activating protein 21-mediated regulation of prostate cancer associated 3 gene in prostate cancer cell.
Braz J Med Biol Res
June 2024
Laboratório de Genética e Biotecnologia, Instituto de Biotecnologia, Universidade Federal de Uberlândia, Patos de Minas, MG, Brasil.
The overexpression of the prostate cancer antigen 3 (PCA3) gene is well-defined as a marker for prostate cancer (PCa) diagnosis. Although widely used in clinical research, PCA3 molecular mechanisms remain unknown. Herein we used phage display technology to identify putative molecules that bind to the promoter region of PCA3 gene and regulate its expression.
View Article and Find Full Text PDFSilencing of ARHGAP21, a Rho GTPase activating protein (RhoGAP), reduces the growth of prostate cancer xenografts in NOD/SCID mice.
Biochim Biophys Acta Mol Cell Res
April 2023
Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Sao Paulo, Brazil.
Deficiency of ARHGAP21 alters megakaryocytic cell lineage responses and enhances platelet hemostatic function.
Biochim Biophys Acta Mol Cell Res
May 2021
Hematology and Transfusion Medicine Center, University of Campinas. Campinas, Sao Paulo, Brazil; Department of Pharmaceutical Sciences, Federal University of Sao Paulo. Diadema, Sao Paulo, Brazil. Electronic address:
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.
Elife
July 2017
Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, United Kingdom.
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signaling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β-Arrestin1. Because β-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that PTEN controls Cdc42 -dependent morphogenic processes through a β-Arrestin1-ARHGAP21 complex.
View Article and Find Full Text PDFARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.
Biochim Biophys Acta
February 2013
Hematology and Hemotherapy Center, University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, INCTS, Campinas, São Paulo, Brazil.
Background: Several Rho GTPase-activating proteins (RhoGAPs) are implicated in tumor progression through their effects on Rho GTPase activity. ARHGAP21 is a RhoGAP with increased expression in head and neck squamous cell carcinoma and with a possible role in glioblastoma tumor progression, yet little is known about the function of ARHGAP21 in cancer cells. Here we studied the role of ARHGAP21 in two prostate adenocarcinoma cell lines, LNCaP and PC3, which respectively represent initial and advanced stages of prostate carcinogenesis.
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