Explainable Artificial Intelligence (XAI) makes AI understandable to the human user particularly when the model is complex and opaque. Local Interpretable Model-agnostic Explanations (LIME) has an image explainer package that is used to explain deep learning models. The image explainer of LIME needs some parameters to be manually tuned by the expert in advance, including the number of top features to be seen and the number of superpixels in the segmented input image. This parameter tuning is a time-consuming task. Hence, with the aim of developing an image explainer that automizes image segmentation, this paper proposes Ensemble-based Genetic Algorithm Explainer (EGAE) for melanoma cancer detection that automatically detects and presents the informative sections of the image to the user. EGAE has three phases. First, the sparsity of chromosomes in GAs is determined heuristically. Then, multiple GAs are executed consecutively. However, the difference between these GAs are in different number of superpixels in the input image that result in different chromosome lengths. Finally, the results of GAs are ensembled using consensus and majority votings. This paper also introduces how Euclidean distance can be used to calculate the distance between the actual explanation (delineated by experts) and the calculated explanation (computed by the explainer) for accuracy measurement. Experimental results on a melanoma dataset show that EGAE automatically detects informative lesions, and it also improves the accuracy of explanation in comparison with LIME efficiently. The python codes for EGAE, the ground truths delineated by clinicians, and the melanoma detection dataset are available at https://github.com/KhaosResearch/EGAE.
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http://dx.doi.org/10.1016/j.compbiomed.2023.106613 | DOI Listing |
Bioengineering (Basel)
December 2024
Department of Electronic Computational Equipment Design, National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 03056 Kyiv, Ukraine.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and neuropsychiatric symptoms resulting from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). Dopamine transporter scan (DATSCAN), based on single-photon emission computed tomography (SPECT), is commonly used to evaluate the loss of dopaminergic neurons in the striatum. This study aims to identify a biomarker from DATSCAN images and develop a machine learning (ML) algorithm for PD diagnosis.
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
AIDA Lab. College of Computer and Information Sciences (CCIS), Prince Sultan University, Riyadh, Saudi Arabia.
The development of deep learning algorithms has transformed medical image analysis, especially in brain tumor recognition. This research introduces a robust automatic microbrain tumor identification method utilizing the VGG16 deep learning model. Microscopy magnetic resonance imaging (MMRI) scans extract detailed features, providing multi-modal insights.
View Article and Find Full Text PDFComput Biol Med
February 2025
School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China. Electronic address:
Artif Intell Med
February 2025
Universidad Politécnica de Cartagena, 30202 Cartagena, Spain. Electronic address:
In this work, we present a multi-modal machine learning method to automate early glaucoma diagnosis. The proposed methodology introduces two novel aspects for automated diagnosis not previously explored in the literature: simultaneous use of ocular fundus images from both eyes and integration with the patient's additional clinical data. We begin by establishing a baseline, termed monocular mode, which adheres to the traditional approach of considering the data from each eye as a separate instance.
View Article and Find Full Text PDFNeuroimage
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China. Electronic address:
The apolipoprotein E (APOE) ɛ4 allele is a recognized genetic risk factor for Alzheimer's Disease (AD). Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. However, how APOE ɛ4 regulates brain functional connectivity (FC) and consequently affects the levels of cognitive impairment in AD patients remains unknown.
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