Methamphetamine is one of the most commonly used illicit drugs during pregnancy. Most studies investigating the impact of maternal use of methamphetamine on children have focused on neurological outcomes. In contrast, cardiovascular outcomes in these children have not been characterized. Recent studies in rodents provide evidence that prenatal exposure to methamphetamine induces changes in cardiac gene expression, changes in the heart's susceptibility to ischemic injury, and changes in vascular function that may increase the risk of developing cardiovascular disorders later in life. Importantly, these changes are sex-dependent. This review summarizes our current understanding of how methamphetamine use during pregnancy impacts the cardiovascular function of adult offspring and highlights gaps in our knowledge of the potential cardiovascular risks associated with prenatal exposure to methamphetamine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10563036 | PMC |
| http://dx.doi.org/10.1139/bcb-2022-0349 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prenatal Methamphetamine Exposure Impairs Helping Behaviour in Male Offspring: The Possible Role of miR-223 and NLRP3 Inflammasomes in the Amygdala.
Int J Dev Neurosci
February 2025
Department of Anatomical Sciences and Cognitive Neurosciences, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
The increasing prevalence of methamphetamine abuse among women, particularly pregnant females, is a global concern. Methamphetamine can readily cross anatomical barriers like the blood-placenta barrier and cause detrimental impacts on the growing fetus. The current research evaluated the effects of prenatal methamphetamine exposure on helping behaviour and neuroinflammatory cascade in the amygdala of male offspring.
View Article and Find Full Text PDFDissecting the neuronal mechanisms of pinoresinol against methamphetamine addiction based on network and experimental pharmacology.
Phytomedicine
December 2024
Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, PR China; Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address:
Article Synopsis
- Addiction is a chronic brain disease associated with drug-seeking behavior, and Flos Daturae (FD) is being studied for its potential in addiction treatment, although its effective components are not well understood.
- The study aimed to investigate the impact of individual ingredients in FD on methamphetamine addiction, utilizing advanced techniques like LC-MS/MS, molecular docking, and behavioral experiments to identify specific targets and mechanisms.
- Findings revealed that pinoresinol (PINL), a key component of FD, effectively reduced methamphetamine-seeking behavior by specifically targeting the D1 dopamine receptor and its associated pathways, suggesting a targeted approach for addiction treatment.
Diagnosis and management of congenital syphilis: Avoiding missed opportunities.
Paediatr Child Health
November 2024
Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario, Canada.
Congenital syphilis can result in pregnancy loss and substantial morbidity in newborns. The current epidemic of congenital syphilis in Canada (especially Western Canada) is a preventable public health emergency. Rates indicate a lack of control of syphilis within the community and insufficient public health resources to prevent spread that predate the COVID-19 pandemic.
View Article and Find Full Text PDFThe modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition.
Life Sci
January 2025
College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei Province, China; Hainan Tropical Forensic Medicine Academician Workstation, Haikou, Hainan Province, China. Electronic address:
Article Synopsis
- - The study investigates how cholecystokinin (CCK) receptors, specifically CCK1 receptors, play a role in methamphetamine (METH)-induced addiction by affecting the nucleus accumbens core (NAcC) and its connections with other brain areas.
- - Using a mouse model, researchers created a condition that mimics METH addiction and explored the effects of genetically knocking out CCK receptor subtypes to understand their specific roles in the METH addiction process.
- - Results showed that disruption of CCK1R in NAcC hindered the development of METH-induced conditioned place preference and altered neuronal excitability, indicating that CCK1R is essential for the synaptic changes in the
Incidence and Outcomes of Pregnant Trauma Patients With Positive Urine Toxicology: A Southern California Multicenter Study.
Am Surg
October 2024
University of California, Irvine, Department of Surgery, Division of Trauma, Burns and Surgical Critical Care, Orange, California, USA.
Article Synopsis
- The study examines the impact of illicit substance use during pregnancy, noting a 4-fold increase over two decades and its negative effects on mothers and fetuses.
- A multicenter retrospective analysis from 2016 to 2021 included 852 pregnant trauma patients (PTPs), with 9.8% testing positive for substances, primarily THC and methamphetamine.
- Findings showed that PTPs with positive urine toxicology had higher rates of blunt head injuries, extremity injuries, domestic violence incidents, and uterine contractions, but similar maternal complication rates compared to those who tested negative.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!