Communicating the diagnosis of Down Syndrome to a couple of parents is never easy, whether before or after birth. As doctors, we must certainly rely on our own relational skills, but it is also necessary to be confident in some general indications, which are often overlooked in the strict hospital routine. This article is intended as a summary of the main articles published on this subject in the international literature, collecting and summarising the most important indications that have emerged in years of medical practice all over the world as well as in our personal experience. The diffusion of these guidelines is essential to help the doctor in this difficult task, on which there is often little training, and above all to guarantee to the parents the least traumatic communication possible.
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http://dx.doi.org/10.1186/s13052-023-01419-6 | DOI Listing |
J Multidiscip Healthc
January 2025
Department of Nursing, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, People's Republic of China.
Objective: This study aimed to assess the determinants of demoralization syndrome among patients with breast cancer (BC) in the southwestern region of China.
Methods: This investigation constituted a single-center cross-sectional study in which 176 patients with BC were surveyed through a questionnaire covering the current status of demoralization syndrome and social support.
Results: Majority of patients with BC developed moderate-to-severe levels of demoralization.
J Voice
January 2025
School of Nursing, Peking University, Beijing 100191, China. Electronic address:
Background: With an increasing prevalence of frailty among older adults, effective classification and management strategies for frailty have become imperative. Voice biomarkers, offering insights into the overall health status of older adults, hold promise for enhancing the management of this multifaceted geriatric syndrome.
Objectives: This scoping review aims to consolidate existing knowledge regarding the relationship between frailty and voice biomarkers.
The primary concern among adults with regard to their hearing is the difficulty in comprehending speech, particularly in noisy environments. The constant need to listen attentively leads to heightened frustration, fatigue and decreased concentration. According to research, high-frequency hearing loss could have negative implications on speech perception and make it even harder to communicate.
View Article and Find Full Text PDFPharmaceutics
January 2025
Section of Immunology, Guangdong Provincial Academy of Chinese Medical Sciences, 55 Nei Huan Xi Lu, College Town, Guangzhou 510006, China.
Psoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-immune cells participate in psoriatic immunopathology.
View Article and Find Full Text PDFJ Clin Med
January 2025
Disturbances of Growth and Development on Children Research Center, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is increasingly recognized as a condition affecting not only adults but also children and adolescents. While children often experience milder acute COVID-19 symptoms compared to adults, some develop persistent physical, psychological, and neurological symptoms lasting for weeks or months after initial infection. The most commonly reported symptoms include debilitating fatigue, respiratory issues, headaches, muscle pain, gastrointestinal disturbances, and cognitive difficulties, which significantly impact daily activities, schooling, and social interactions.
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