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Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence. | LitMetric

AI Article Synopsis

  • - The study investigates the relationship between two opportunistic pathogens, Acinetobacter baumannii and Klebsiella pneumoniae, which are often found together in severe lung infections, highlighting their potential synergistic interactions.
  • - Through genomic analysis and various assays, the research uncovers how these bacteria affect each other's antimicrobial resistance and virulence during co-infection, including K. pneumoniae supporting A. baumannii with by-products from sugar fermentation.
  • - Findings reveal that A. baumannii can also protect K. pneumoniae from the antibiotic cefotaxime, illustrating distinct interactions that help explain their coexistence in complex infections.

Article Abstract

Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens frequently co-isolated from polymicrobial infections. The infections where these pathogens co-exist can be more severe and recalcitrant to therapy than infections caused by either species alone, however there is a lack of knowledge on their potential synergistic interactions. In this study we characterise the genomes of A. baumannii and K. pneumoniae strains co-isolated from a single human lung infection. We examine various aspects of their interactions through transcriptomic, phenomic and phenotypic assays that form a basis for understanding their effects on antimicrobial resistance and virulence during co-infection. Using co-culturing and analyses of secreted metabolites, we discover the ability of K. pneumoniae to cross-feed A. baumannii by-products of sugar fermentation. Minimum inhibitory concentration testing of mono- and co-cultures reveals the ability for A. baumannii to cross-protect K. pneumoniae against the cephalosporin, cefotaxime. Our study demonstrates distinct syntrophic interactions occur between A. baumannii and K. pneumoniae, helping to elucidate the basis for their co-existence in polymicrobial infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911699PMC
http://dx.doi.org/10.1038/s41467-023-36252-2DOI Listing

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