Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of C.H. Wright (Violaceae).

From fruits, 3-Nor-4β-friedelan-24-ol () and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (), new derivatives alongside, 28-hydroxyfriedelan-3-one (), friedelin (), 3,3',4,4',5'-pentamethylcoruleoellagic acid (), hexamethylcoruleoellagic acid (), 3',4,4',5,5'-pentamethylcoruleoellagic acid (), and fatty compounds were isolated and characterized using HRESIMS, EIMS, 1D and 2D NMR. enzyme inhibition of compounds and were evaluated on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, urease and tyrosinase. Against AChE and BChE, the phenolic compounds and had good activity probably due to the phenolic nature and methoxy substituents. Compounds and exhibited good α-glucosidase inhibition especially compound whose IC = 42.45 ± 0.46 µg/mL was close that of acarbose (IC = 20.52 ± 0.84 µg/mL) standard drug. Urease and tyrosinase were appreciably inhibited by the compounds. Overall results of enzyme inhibitory assays indicate fruits and its constituents as potential remedy for enzymatic disorders.