Antiproliferative -terphenyl derivatives isolated from the fungus .

The ethanol extract of the fungus collected from north-central British Columbia, Canada, showed strong antiproliferative activity. Bioassay-guided purification using liquid-liquid extraction and Sephadex LH-20 size-exclusion chromatography, followed by HPLC-MS and 1D/2D NMR analyses, led to the isolation of five known compounds; four -terphenyl (-) derivatives and one phenolic aldehyde (). Compounds , , and were isolated for the first time from the genus. The cytotoxicity MTT assay showed that compounds - have antiproliferative activity against human cervical cancer cells (HeLa). For compounds , this is the first report of their antiproliferative activity against cancer cells. For compound , this is the first report on its bioactivity. To our knowledge, this is the first description of the isolation of bioactive constituents from .