Compared with conventional, solution-phase approaches, solid-state reaction methods can provide unique access to novel synthetic targets. Nanothreads-one-dimensional diamondoid polymers formed through the compression of small molecules-represent a new class of materials produced via solid-state reactions, however, the formation of chemically homogeneous products with targeted functionalization represents a persistent challenge. Through careful consideration of molecular precursor stacking geometry and functionalization, we report here the scalable synthesis of chemically homogeneous, functionalized nanothreads through the solid-state polymerization of 2,5-furandicarboxylic acid. The resulting product possesses high-density, pendant carboxyl functionalization along both sides of the backbone, enabling new opportunities for the post-synthetic processing and chemical modification of nanothread materials applicable to a broad range of potential applications.
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http://dx.doi.org/10.1002/anie.202217023 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
Alkaline phosphatase (ALP) is a biomarker for many diseases, and monitoring its activity level is important for disease diagnosis and treatment. In this study, we used the microdroplet technology combined with an laser-induced polymerization method to prepare the Ag nanoparticle (AgNP) doped hydrogel microbeads (HMBs) with adjustable pore sizes that allow small molecules to enter while blocking large molecules. The AgNPs embedded in the hydrogel microspheres can provide SERS activity, improving the SERS signal of small molecules that diffuse to the AgNPs.
View Article and Find Full Text PDFJ Biotechnol
January 2025
Johns Hopkins Biomedical Engineering; Johns Hopkins University Department of Molecular Biology and Genetics, Baltimore, Maryland, USA; Johns Hopkins University Department of Medicine, Division of Infectious Disease, Baltimore, Maryland, USA. Electronic address:
Chinese Hamster Ovary (CHO) cells produce monoclonal antibodies and other biotherapeutics at industrial scale. Despite their ubiquitous nature in the biopharmaceutical industry, little is known about the behaviors of individual transfected clonal CHO cells. Most CHO cells are assessed on their stability, their ability to produce the protein of interest over time.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2025
Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation, Xi'an University of Science and Technology, Xi'an 710054 China.
The coal molecular structure in micro-areas plays a critical role in matrix thermal conduction and volatile generation during the pyrolysis of tar-rich coal. However, as a major maceral contributing to hydrocarbon generation, the molecular structures of different micro-areas in vitrinite show heterogeneity, which still lacks research. Micro-FTIR technology was used in this study to characterize the molecular structure in different micro-areas of tar-rich coal with varying tar yields.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, People's Republic of China.
Deuterated compounds have broad applications across various fields, with dehalogenative deuteration serving as an efficient method to obtain these molecules. However, the diverse electronic structures of active sites in the heterogeneous system and the limited recyclability in the homogeneous system significantly hinder the advancement of dehalogenative deuteration. In this study, we present a catalyst composed of copper single-atom sites anchored within an ordered mesoporous nitrogen-doped carbon matrix, synthesized via a mesopore confinement method.
View Article and Find Full Text PDFRSC Adv
January 2025
Nano-Science Center & Department of Chemistry, University of Copenhagen Universitetsparken 5 2100 København Ø Denmark
pH remains the most important chemical parameter and must be monitored for positive outcomes in areas as different as cheese making and fertilisation (IVF). Where blood gas analysers enable patient monitoring, starter cultures in cheese manufacturing are still monitored using conventional pH electrodes. Here, we present a homogeneous multiwell plate sensor for monitoring pH, with the same sensitivity as a pH electrode.
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