Expression and Clinical Significance of in Gastric Cancer.

Objective: The aim of this research was to investigate the expression of and its potential clinical significance in gastric cancer (GC).

Methods: In this study, we detected the protein expression levels of in GC tissues and adjacent normal tissues by immunohistochemistry (IHC) and analysed the relationship between the protein expression levels of 2 and clinicopathological parameters of GC patients. Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan-Meier Plotter were used to verify the diagnostic and prognostic values of . Proteins interacting with were predicted using the SRING database.

Results: Our results showed that the protein expression levels of in GC tissues were lower than those in adjacent normal tissues (all < 0.05), and the protein expression level of was correlated with lymph node metastasis and TNM stage of GC patients (all < 0.05). Aberrant overexpression of was associated with poor prognosis of GC patients. Proteins such as VR1, TRPV1, LHFPL5, STOM, TRPA1 and STOML3 had obvious interactions with PIEZO2 ( = 0.00213).

Conclusion: In summary, our current study identified as a promising target for early diagnosis and as a potential prognostic biomarker in GC patients.