AI Article Synopsis
- Isoflurane is a commonly used inhalational anesthetic known for its quick and quiet induction of anesthesia, but its adverse reproductive effects are not fully understood.
- The study aimed to assess how acute isoflurane exposure affects sperm quality in mice, both immediately before euthanasia and 20 days later.
- Findings revealed that acute exposure significantly decreases sperm motility and leads to increased damage and apoptosis in sperm cells, potentially impacting reproductive research outcomes long after the exposure.
Article Abstract
Isoflurane, an inhalational anesthetic from the halogenated group, has been increasingly used in the medical and scientific fields. Due to its characteristics, it is capable of inducing anesthesia quickly and quietly; however, the adverse effects resulting from its use have not yet been fully elucidated, especially with regard to reproductive aspects. Considering its common use in research laboratories, whether for performing surgical procedures or for prior exposure to euthanasia, knowledge about its interference in sperm parameters of experimental models characterizes an important study goal. The aim of the present study was to determine the interference of acute exposure to isoflurane on the sperm quality of mice, both immediately previous to euthanasia and in later evaluation, twenty days after a single anesthetic exposure. Our results demonstrate that acute anesthetic exposure reduces sperm motility and is responsible for the formation of damaged sperm cells that are prone to apoptosis, which may affect the outcome of reproductive experiments even 20 days after exposure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/01480545.2023.2176513 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!