AI Article Synopsis
- Microneedle technology is effective in reducing hypertrophic scarring in both animals and humans by utilizing physical contact inhibition.
- The study focuses on the impact of different microneedle materials on scar formation, specifically using a rabbit ear hypertrophic scar model over 42 days.
- Among various materials tested, polymethylmethacrylate microneedles showed the best results in lowering tissue fibrosis and expressions of key proteins and mRNA, while other materials like polycarbonates and polyurethanes also suppressed certain biomarker expressions but were less effective overall.
Article Abstract
Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles. Therefore, this article examines this key point on a rabbit ear hypertrophic scar model. We monitor the thickness of the scars, and the expression of α-SMA and Ki-67 protein, and TGF-β1 mRNA in a period of 42 days. Among microneedles made of 6 polymeric materials and stainless steel, polymethylmethacrylate microneedles present superiority in all aspects including the reduction of tissue fibrosis, and the expression of α-SMA, Ki-67 protein and TGF-β1 mRNA. On the other hand, polycarbonates, polyurethane, and polylactic--glycolic acid microneedles could suppress three biomarker expressions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890948 | PMC |
| http://dx.doi.org/10.1039/d2na00604a | DOI Listing |
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