Objectives: This study aimed to synthesise a drug-delivery system based on a porous polymer hydrogel, with antimicrobial properties against Porphyromonas gingivalis and potential to be used in tissue regeneration.
Material And Methods: 2-Hydroxyethyl methacrylate monomers were polymerised using thermal and photoactivation in the presence of silver nitrate (AgNO) and/or chlorhexidine digluconate. Poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing silver nanoparticles (AgNPs) and/or 0.12% chlorhexidine (CHX) were produced and characterised using cryo-SEM and confocal microscopy. Hydrogel degradation and leaching of AgNP were tested for 1.5 months. The antimicrobial properties were tested against P. gingivalis using broth culture system and disk diffusion tests.
Results: Our methodology manufactured porous polymeric hydrogels doped with AgNPs and CHX. Hydrogels showed a successful delivery of CHX and sustainable release of AgNPs in a steady hydrogel degradation rate determined based on the weight loss of samples. Hydrogels with AgNPs or CHX had a significant antimicrobial effect against P. gingivalis, with CHX-hydrogels exhibiting a stronger effect than AgNP-hydrogels in the short-term assessment. AgNP-CHX hydrogels showed a compounded antimicrobial effect, whereas control hydrogels containing neither AgNPs nor CHX had no influence on bacterial growth (P < .05).
Conclusions: The dual-cured pHEMA hydrogel loaded with antimicrobial agents proved to be an efficient drug-delivery system against periodontopathogens, with the potential to be used as a scaffold for tissue regeneration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213806 | PMC |
| http://dx.doi.org/10.1016/j.identj.2023.01.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the Effect of Chitosan-Based Irrigation Solutions on the Bond Strength of Mineral Trioxide Aggregate to Bulk-Fill Composite.
J Funct Biomater
December 2024
Department of Endodontics, Faculty of Dentistry, Gazi University, 06490 Ankara, Türkiye.
Bond strength between repair and restorative materials is crucial for endodontic success. This study assessed the effects of the following final irrigation solutions on the bond strength of mineral trioxide aggregate (MTA) to a bulk-fill composite: (1) 17% Ethylenediamine tetraacetic acid (EDTA); (2) 2% Chlorhexidine (CHX); (3) 0.2% chitosan; (4) 0.
View Article and Find Full Text PDFAssessing the impact of an environmentally friendly approach on irreversible dental hydrocolloid performance.
Sci Rep
December 2024
Oral Technology, Dental School, Medical Faculty, University Hospital Bonn, Bonn, Germany.
Background: Impression materials can harbour microorganisms from saliva and blood, posing cross-contamination risks. However, post-setting disinfection might compromise the dimensional accuracy and mechanical properties of alginates. Hence, it was the aim of this research to assess the detail reproduction, tear strength, elastic recovery, and surface quality of the gypsum model of newly developed dental alginates with inherent antimicrobial properties.
View Article and Find Full Text PDFEnhancing Dental Alginate with , and Green Silver Nanoparticles: A Nature-Enhanced Approach for Superior Infection Control.
Gels
September 2024
Oral Technology, Dental School, Medical Faculty, University Hospital Bonn, 53111 Bonn, Germany.
Objectives: The study addresses the challenge of cross-infection in dentistry, focusing on improving disinfection protocols for dental hydrocolloid gel materials. This research aimed to incorporate chlorhexidine, natural plant extracts, and green-synthesized silver nanoparticles (AgNPs) into dental alginate to enhance safety and hygiene standards in dental practices.
Methods: Conventional dental alginate served as the control, with experimental groups including alginate modified with 0.
Antibacterial Effect of Silver Nanoparticles against Oral Biofilms in Subjects with Motor and Intellectual Disabilities.
J Funct Biomater
July 2024
Master Program in Dental Sciences, Stomatology Department, Institute of Biomedical Sciences, Autonomous University of Juarez City (UACJ), Envolvente del PRONAF and Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico.
Background: Motor and intellectual disabilities (MIDs) represent a great challenge for maintaining general health due to physical and cognitive limitations, particularly in the maintenance and preservation of oral health. Silver nanoparticles (AgNPs) have emerged as a promising therapeutic tool for bacterial control, including oral biofilms; however, knowledge of the bactericidal effectiveness of oral biofilms from patients with MIDs is insufficient. This study aims to determine the antimicrobial effect of AgNPs on different oral biofilms taken from patients with and without MIDs.
View Article and Find Full Text PDFPhycocyanin-loaded silver nanoparticles activated with photodynamic therapy and Nd: YAG laser for caries-affected dentin disinfection: Impact on Streptococcus mutans survival rate and shear bond strength to the tooth-colored restorative material.
Photodiagnosis Photodyn Ther
June 2024
Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
To assess the impact of various cavity disinfectants PC-PDT (Phycocyanin activated by Photodynamic therapy), PC@AgNPs-PDT (Phycocyanin and silver nanoparticles activated by PDT), and Nd: YAG laser on the survival rate of S.mutans and the bond integrity of composite restoration METHODS: Sixty human mandibular molars that scored 4 and 5 based on ICDAS criteria were included. The infected dentin was removed while the CAD was preserved based on visual, tactile, and staining assessment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!