Objectives: CD103CD8T cells is a subtype of T cells with excellent tumor killing ability and it could response to immune checkpoint blockade therapy in several types of cancer, but the phenotype, role and molecular mechanism CD103CD8T cells in the OSCC still unclear.
Materials And Methods: The distribution and phenotype of CD103CD8T cells were investigated by performing multiplexed immunohistochemistry on human OSCC tissue microarray and flow cytometric analysis of fresh OSCC tumor-infiltrating lymphocytes (TILs). By in vivo use of anti-CD103 monoclonal antibody (mAb) in the 4MOSC1 tumor-bearing mouse model, CD103CD8T cell infiltration and cytotoxicity was clarified.
Results: The majority of CD8T cells in both human and animal OSCC intra-tumoral region were CD103CD8T cells with high expression levels of cytotoxic molecules, which can be impaired by CD103 blockade. In addition, combined use of anti-CD103 mAb with anti-CTLA-4 mAb displayed impaired immune checkpoint blockade therapy efficiency.
Conclusion: CD103CD8T cells are the major intra-tumoral subset of CD8T cells in both animal and human OSCC, and that CD103CD8T cells demonstrate remarkable tumor-infiltrating and tumor-killing properties, thereby CD103CD8T cells may critical for anti-CTLA-4 immunotherapy in OSCC.
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| http://dx.doi.org/10.1016/j.oraloncology.2023.106331 | DOI Listing |
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