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CD206 macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia. | LitMetric

AI Article Synopsis

  • Recent research investigates how early macrophages influence the development of microglia in the embryonic mouse brain, though evidence for this process is still lacking.!
  • Using techniques like cell tracking and genetic labeling, the study demonstrates that specific macrophages (CD206+) migrate into the brain's pallium during early development, beginning around embryonic day 12.!
  • The findings suggest that a vital pathway exists for microglial colonization, occurring via a route from the roof plate to the ventricle and then into the pallium, highlighting the dynamic relationship between these cell types during brain development.!

Article Abstract

The relationships between tissue-resident microglia and early macrophages, especially their lineage segregation outside the yolk sac, have been recently explored, providing a model in which a conversion from macrophages seeds microglia during brain development. However, spatiotemporal evidence to support such microglial seeding in situ and to explain how it occurs has not been obtained. By cell tracking via slice culture, intravital imaging, and Flash tag-mediated or genetic labeling, we find that intraventricular CD206 macrophages, which are abundantly observed along the inner surface of the mouse cerebral wall, frequently enter the pallium at embryonic day 12. Immunofluorescence of the tracked cells show that postinfiltrative macrophages in the pallium acquire microglial properties while losing the CD206 macrophage phenotype. We also find that intraventricular macrophages are supplied transepithelially from the roof plate. This study demonstrates that the "roof plate→ventricle→pallium" route is an essential path for microglial colonization into the embryonic mouse brain.

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Source
http://dx.doi.org/10.1016/j.celrep.2023.112092DOI Listing

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