AI Article Synopsis

  • A decompressive craniectomy (DC) is a surgical method used to treat severe intracranial pressure after traumatic brain injuries, and this study investigates its link to post traumatic hydrocephalus (PTH).
  • A review of data from a neurosurgical center included 65 patients with severe TBI, monitoring for evidence of PTH, defined by symptoms like ventricular dilation and the need for a shunt.
  • Results showed that younger patients were more likely to develop PTH, with cerebellar hematomas being a significant predictor of this condition following DC.

Article Abstract

Background: A decompressive craniectomy (DC) is a surgical procedure sometimes utilized to manage refractory intracranial hypertension following severe traumatic brain injury (sTBI). The previous studies have established a relationship between DC and post traumatic hydrocephalus (PTH). This study aimed to identify the factors responsible for developing shunt-amenable PTH in patients who underwent DC following sTBI.

Methods: A review of a prospectively collected database of all patients admitted with severe TBI in a tertiary neurosurgical center in North-west England between January 2012 and May 2022 was performed. PTH was defined as evidence of progressive ventricular dilatation, clinical deterioration, and/or the eventual need for cerebrospinal fluid diversion (i.e., a ventriculoperitoneal shunt). Statistical analysis was carried out using IBM SPSS versus 28.0.1.

Results: Sixty-five patients met the eligibility criteria and were included in the study. The mean age of the PTH group was 31.38 ± 14.67, while the mean age of the non-PTH group was slightly higher at 39.96 ± 14.85. No statistically significant difference was observed between the two groups' mechanisms of traumatic injury ( = 0.945). Of the predictors investigated, cerebellar hematoma (and contusions) was significantly associated with PTH ( = 0.006).

Conclusion: This study concludes that cerebellar hematoma (and contusions) are associated with developing PTH in patients undergoing DC.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899461PMC
http://dx.doi.org/10.25259/SNI_1121_2022DOI Listing

Publication Analysis

Top Keywords

post traumatic
8
traumatic hydrocephalus
8
decompressive craniectomy
8
pth patients
8
cerebellar hematoma
8
hematoma contusions
8
contusions associated
8
pth
6
factors associated
4
associated post
4

Similar Publications

Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity.

Nutrients

December 2024

Department of Anesthesiology and Critical Care, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.

The gut-brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores the complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting its effect on brain health, particularly in the context of depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing its bioavailability and predisposing to neuroinflammation and neurotoxicity.

View Article and Find Full Text PDF

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), and neuroinflammation in the TBI. We delineate the dual aspects of TBI: the immediate mechanical damage (primary injury) and the subsequent biological processes (secondary injury) that exacerbate neuronal damage.

View Article and Find Full Text PDF

Traumatic optic neuropathy (TON) has been regarded a vision-threatening condition caused by either ocular or blunt/penetrating head trauma, which is characterized by direct or indirect TON. Injury happens during sports, vehicle accidents and mainly in military war and combat exposure. Earlier, we have demonstrated that remote ischemic post-conditioning (RIC) therapy is protective in TON, and here we report that AMPKα1 activation is crucial.

View Article and Find Full Text PDF

Severity-Dependent Long-Term Post-Traumatic Changes in the Circulating Oxylipin Profile.

Int J Mol Sci

December 2024

Research Laboratories and Clinic of Orthopedics, Trauma and Plastic Surgery, Leipzig University and University Hospital Leipzig, 04103 Leipzig, Germany.

Trauma causes the breakdown of membrane phospholipids and the subsequent degradation of the released polyunsaturated fatty acids (PUFAs) to partially bioactive oxylipins. Here, we screened for circulating PUFAs and oxylipins in patients (n = 34) differing from those of uninjured controls (n = 25) and analyzed their diagnostic potential. Patients were followed up for 1 to 240 h after minor/moderate, severe, and very severe injuries.

View Article and Find Full Text PDF

: Post-traumatic stress disorder (PTSD) is a debilitating condition worldwide. The limited effectiveness of current psychological and pharmacological treatments has motivated studies on meditation techniques. This study is a comprehensive, multiple-treatments meta-analysis comparing the effectiveness of different categories of meditation in treating PTSD.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!