An Introduction to Stereology with Applications to the Glomerulus.

Glomerular Dis

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Published: October 2021

Background: Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. Without a proper understanding of its principles, though, errors may be made in the quantitative reporting of structural research results.

Summary: This review article attempts to explain and justify the basic principles of stereology as applied to the glomerulus in a simple and accessible way. A few common errors in application are described. The strengths and weaknesses of "biased" (model-based) stereology are described as well as the basics of design-based ("unbiased") stereology.

Key Messages: Stereology is a useful body of theory and practices when quantitation of structural histological features of the glomerulus is desired.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677735PMC
http://dx.doi.org/10.1159/000519719DOI Listing

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