AI Article Synopsis
- The study investigates how urate-lowering treatment with febuxostat affects kidney outcomes in elderly patients with high cardiovascular risk and high uric acid levels.
- It was part of the FREED trial, which included 1,070 patients divided into febuxostat and non-febuxostat groups.
- Results showed that febuxostat significantly reduced the risk of worsening macroalbuminuria by 56%, but did not significantly alter other kidney-related outcomes.
Article Abstract
Effect of urate-lowering on renal outcomes in patients at high-risk for cardiovascular disease with hyperuricemia without gout is not known. We conducted a post hoc analysis of a randomized trial (Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy [FREED]). The FREED trial enrolled 1070 asymptomatic, hyperuricemic elderly patients with at least one risk factor for cardiovascular disease, divided into febuxostat (n = 537) and non-febuxostat (n = 533) groups. We compared the effect of these treatments on renal outcomes including 40% decline in estimated glomerular filtration rate, new onset of microalbuminuria and development or worsening macroalbuminuria. The relative risk of developing or worsening macroalbuminuria was 56% lower in the febuxostat group (hazard ratio, 0.44; 95% CI, 0.24-0.82; P = 0.0098). However, the risks for other outcomes were comparable. In patients with asymptomatic hyperuricemia without gout, febuxostat reduces the risk of development or worsening of macroalbuminuria.
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| http://dx.doi.org/10.1038/s41440-023-01198-x | DOI Listing |
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