The shape of a neuron changes dramatically during development. New work reports a novel septin cytoskeleton network that is important in establishing proper neuronal morphology.
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Sequential recruitment of F-BAR proteins controls cytoskeletal crosstalk at the yeast bud neck.
Curr Biol
January 2025
Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA. Electronic address:
In vivo functions of the septin and actin cytoskeletons are closely intertwined, yet the mechanisms underlying septin-actin crosstalk have remained poorly understood. Here, we show that the yeast-bud-neck-associated Fes/CIP4 homology Bar-amphiphysin-Rvs (F-BAR) protein suppressor of yeast profilin 1 (Syp1)/FCHo uses its intrinsically disordered region (IDR) to directly bind and bundle filamentous actin (F-actin) and to physically link septins and F-actin. Interestingly, the only other F-BAR protein found at the neck during bud development, Hof1, has related activities and also potently inhibits the bud-neck-associated formin Bnr1.
View Article and Find Full Text PDFMechanisms of regulated cell death during plant infection by the rice blast fungus Magnaporthe oryzae.
Cell Death Differ
January 2025
The Sainsbury Laboratory, University of East Anglia, Norwich, UK.
Fungi are the most important group of plant pathogens, responsible for many of the world's most devastating crop diseases. One of the reasons they are such successful pathogens is because several fungi have evolved the capacity to breach the tough outer cuticle of plants using specialized infection structures called appressoria. This is exemplified by the filamentous ascomycete fungus Magnaporthe oryzae, causal agent of rice blast, one of the most serious diseases affecting rice cultivation globally.
View Article and Find Full Text PDFThe first attempt in synthesis, identification, and evaluation of SEPT9 inhibitors on human oral squamous carcinomas.
Bioorg Chem
January 2025
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address:
Septin 9 (SEPT9), a GTPase, known as the fourth cytoskeleton, is widely expressed in various cells and tissues. The functions of SEPT9 are partly similar to other cytoskeletons as a structure protein. Further, SEPT9 can interact with other cytoskeletons, participating in actin dynamics and microtubule regulation.
View Article and Find Full Text PDFDysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension.
JCI Insight
December 2024
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Article Synopsis
- Ocular hypertension, a key risk factor for glaucoma, is linked to increased activity and stiffness in the trabecular meshwork (TM) due to cellular interactions.
- Previous research identified high levels of septin-9 in TM cells under hypertensive conditions, prompting studies on its overexpression, deficiency, and drug targeting effects.
- Findings indicate that septin-9 impacts intraocular pressure (IOP) regulation, suggesting that modulating septin cytoskeletal organization could be a potential new treatment strategy for glaucoma.
The core septin gene CgSEP5 is associated with formation of infection structures and pathogenicity in Colletotrichum gloeosporioides.
Int J Biol Macromol
December 2024
The Key Laboratory for Silviculture and Conservation of the Ministry of Education, Beijing Forestry University, Beijing 100083, PR China. Electronic address:
Colletotrichum gloeosporioides is a model plant pathogenic fungus, and the appressoria are the main infection structures integral to the pathogenic process. Septin proteins play fundamental roles in facilitating shape alteration and organizing the F-actin cytoskeleton, thereby aiding the invasive growth of various fungi. Herein, we examined the roles of four septin-coding genes (CgSEP3, CgSEP4, CgSEP5, and CgSEP6) in C.
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