A racemic approach towards the synthesis of the ABC (7/7/5) ring system of triterpenoid kadlongilactones is described. The synthesis features two key transformations: (1) conjugate addition followed by iodolactonization to build the -fused 7/7 ring; and (2) conjugate addition-Rubottom oxidation cascade followed by ring-closing metathesis to construct the 7/7/5 tricyclic ring.
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http://dx.doi.org/10.1039/d2ob01701f | DOI Listing |
Mater Horiz
January 2025
Department of Applied Physics and Center for Computational Engineering and Sciences, State University of Campinas, Campinas, São Paulo, Brazil.
The recent synthesis of goldene, a 2D atomic monolayer of gold, has opened new avenues in exploring novel materials. However, the question of when multilayer goldene transitions into bulk gold remains unresolved. This study used density functional theory calculations to address this fundamental question.
View Article and Find Full Text PDFArq Bras Cardiol
January 2025
Programa de Pós-Graduação em Alimentação, Nutrição e Saúde - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.
Background: The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4340) is associated with the pathogenesis of heart failure (HF). This polymorphism may contribute to a greater propensity for severe HF and excess weight.
Objective: To evaluate adiposity, cardiac function, and their association with ACE I/D polymorphism in HF patients.
Front Endocrinol (Lausanne)
January 2025
Department of Obstetrics and Gynecology, The Seventh Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Introduction: Premature ovarian insufficiency (POI) is a condition characterized by ovarian dysfunction occurring before the age of 40, and its etiology is multifactorial, including genetic, immunological, infectious, environmental, and iatrogenic factors, with over half of the cases remaining unexplained. Whether the microbial communities and metabolites in follicular fluid, which is the direct microenvironment for oocyte survival, are related to POI has not been reported.
Methods: In this study, Follicular fluid samples of 26 patients with POI and 27 controls with a normal ovarian reserve were collected and analyzed using 16S rDNA sequencing and untargeted metabolomics.
J Am Chem Soc
January 2025
Center for Electron Microscopy, South China University of Technology, Guangzhou 510640, China.
Poly(triazine imide) (PTI) materials, a class of layered graphitic carbon nitrides, have garnered significant attention for their unique electronic, thermal, and catalytic properties. These properties can be adjusted through postsynthesis treatments. However, the influence of these treatments on the layer stacking modes and local structures within PTI remains largely unexplored.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Life Science, Sichuan Normal University, Chengdu 610066, Sichuan, China.
Inulin, a health-promoting dietary fiber, is efficiently metabolized by Weissella paramesenteroides YT175, a beneficial bacterium. The strain demonstrated a diauxic growth pattern within 48 h, reaching an optical density at 600 nm (OD) of approximately 1.5, accompanied by a significant decrease in pH to around 4.
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