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International consensus on research priorities in hypospadias using a Delphi study approach.
J Pediatr Urol
December 2024
Department of Public Health, College of Health Sciences, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
Introduction: Hypospadias is a common congenital anomaly of the male genitalia that poses significant management and treatment challenges. Gaining a comprehensive understanding of priority research questions in hypospadiology will be essential to reach agreement on the optimal approach to assessment, treatment, and outcome prediction for affected patients.
Methods: We employed a consensus-building Delphi method to identify and prioritize research questions in the hypospadias field.
Postmarketing Safety Surveillance of Topiramate: A Signal Detection and Analysis Study Based on the FDA Adverse Event Reporting System Database.
J Evid Based Med
December 2024
School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, China.
Article Synopsis
- This study investigates adverse events associated with topiramate using data from the FDA Adverse Event Reporting System, aiming to improve its safe clinical use.
- The analysis reviewed 12,168 reports and identified 244 positive signals of adverse reactions, with 21 of these being serious and not listed on the drug label.
- Key serious signals included conditions like hypospadias, spina bifida, and renal dysfunction, highlighting the necessity for ongoing vigilance in monitoring topiramate's safety.
Outcomes of Double-Face Buccal Mucosal Urethroplasty for Treating Anterior Urethral Stricture in Adult Males.
J Coll Physicians Surg Pak
November 2024
Department of Urology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Objective: To assess the results of double-face buccal mucosal graft urethroplasty (BMG) for treating anterior urethral stricture in adult males.
Study Design: An observational study. Place and Duration of the Study: Department of Urology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan, from 2021 to 2022.
Differences in Messenger RNA Expression of Fibulin-1, Elastin, Matrix Metalloproteinase-1, Basic Fibroblast Growth Factor, and α-Smooth Muscle Actin Between the Ventral and Dorsal Tunica Dartos in Patients With Hypospadias and Chordee: Protocol for a Prospective Cohort Study.
JMIR Res Protoc
October 2024
Faculty of Medicine, Universitas Andalas, Padang, Indonesia.
Article Synopsis
- * The study aims to compare the mRNA expression of specific proteins involved in hypospadias development between the ventral and dorsal tunica dartos in children diagnosed with hypospadias and chordee.
- * Currently in the protocol development stage, the study's results are anticipated by the end of 2024 and aim to improve understanding of the condition's underlying mechanisms.
DSD-related attitudes and beliefs held by pediatric endocrinologists and urologists: Insights from the North American disorders/differences of sex development (DSD) clinician survey.
J Pediatr Urol
December 2024
Susan B. Meister Child Health Evaluation and Research (CHEAR) Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Division of Pediatric Psychology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:
Background: Disorders/Differences of Sex Development (DSD) encompass congenital conditions with atypical development of chromosomal, gonadal, or anatomical sex. Due to the rarity and complexity of these conditions, strong evidence for clinical practices is scarce, leading to controversies in management.
Objective: This study, part of a broader project, examines changes over time in the attitudes and beliefs of DSD healthcare providers, focusing on factors contributing to patients' life satisfaction and the influence of medical specialty, gender, and age.
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