AI Article Synopsis
- A study tested a dipstick assay for detecting Taenia solium antigen in urine from 30 patients with neurocysticercosis and 10 healthy individuals.
- The test successfully identified the antigen in 29 out of 30 patients while showing no positive results in healthy controls.
- The findings suggest that this urine antigen test could be a practical tool for diagnosing neurocysticercosis and identifying at-risk patients in regions with limited medical resources.
Article Abstract
We report a proof-of-concept study using a dipstick assay to detect Taenia solium antigen in urine samples of 30 patients with subarachnoid neurocysticercosis and 10 healthy control subjects. Strips were read in blind by two readers. The assay detected antigen in 29 of 30 cases and was negative in all 10 control samples. Although this study was performed in samples from individuals with subarachnoid neurocysticercosis who likely had high circulating antigen levels, it provides the proof of concept for a functional urine antigen point-of-care assay that detects viable cysts. Such an assay could serve to support a clinical diagnosis of suspect neurocysticercosis or to identify patients at risk of developing severe disease in areas where medical resources are limited, providing evidence to refer these individuals for imaging and specialized care as needed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978566 | PMC |
| http://dx.doi.org/10.4269/ajtmh.22-0598 | DOI Listing |
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