Background: Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis, and mainly transmitted via faecal-oral contamination or consumption of contaminated food products. However, limited data on the surface stability and HEV sensitivity to chemical disinfectants are available.
Aim: To establish an HEV-based carrier assay to evaluate its surface stability and the virucidal activity of nine surface disinfectants.
Methods: A recently developed robust HEV-3 cell culture system for an HEV-based carrier assay.
Findings: Alcohol-based disinfectants were insufficient to eliminate HEV infectivity, whereas disinfectants based on aldehyde, peracetic acid, oxygen, and/or quaternary ammonium inactivated HEV.
Conclusion: These findings have strong implications for the recommendation of evidence-based hygiene guidelines to reduce HEV transmission.
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| http://dx.doi.org/10.1016/j.jhin.2023.01.013 | DOI Listing |
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