The COVID-19 pandemic has generated a high level of psychological distress in the general population. The aims of this study were to examine the mental health of men and women in the general population in Israel during the first lockdown. The sample comprised 587 participants (426 females and 161 males), whose age ranged between 16 and 85. They completed the Patient Health Questionnaire-4 (PHQ-4), the Psychosomatic Symptoms Scale, and the Connor-Davidson Resilience Scale (CD-RISC2). Psychological distress was expressed in our measures of depression, anxiety, loneliness, and somatization, in conjunction with high resilience. Women exhibited higher levels of these symptoms than men-but this fluctuates with age, and can match the levels of these symptoms reported by men. Specifically, no difference between the genders was found for loneliness, in age groups 24-39 and 56-85; and for depression, in age groups 40-55 and 56-85. For somatization, the difference is reversed for age group 56-85. In contrast, while women generally scored lower than the men for resilience, this was specifically for age group 16-23. Our findings suggest that young women report more mental health problems, and that men and women may be differentially vulnerable to disaster-related stressors, such as experienced during the pandemic.
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http://dx.doi.org/10.1016/j.psychres.2023.115069 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Protein language models (PLMs) have demonstrated impressive success in modeling proteins. However, general-purpose "foundational" PLMs have limited performance in modeling antibodies due to the latter's hypervariable regions, which do not conform to the evolutionary conservation principles that such models rely on. In this study, we propose a transfer learning framework called Antibody Mutagenesis-Augmented Processing (AbMAP), which fine-tunes foundational models for antibody-sequence inputs by supervising on antibody structure and binding specificity examples.
View Article and Find Full Text PDFJMIR Res Protoc
January 2025
UK Health Security Agency, London, United Kingdom.
Background: Due to advances in treatment, HIV is now a chronic condition with near-normal life expectancy. However, people with HIV continue to have a higher burden of mental and physical health conditions and are impacted by wider socioeconomic issues. Positive Voices is a nationally representative series of surveys of people with HIV in the United Kingdom.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Department of Psychiatry, Yongin Severance Hospital, Yongin, Republic of Korea.
Background: The COVID-19 pandemic has accelerated the digitalization of modern society, extending digital transformation to daily life and psychological evaluation and treatment. However, the development of competencies and literacy in handling digital technology has not kept pace, resulting in a significant disparity among individuals. Existing measurements of digital literacy were developed before widespread information and communications technology device adoption, mainly focusing on one's perceptions of their proficiency and the utility of device operation.
View Article and Find Full Text PDFACS Nano
January 2025
NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisbon 1169-056, Portugal.
The "" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in bridging the gap between research, manufacturing, and clinical applications. Effective communication is key to bridging team gaps, enhancing trust, and resolving conflicts, thereby fostering teamwork and individual growth toward shared goals. Drawing from the success of the COVID-19 vaccine development, we advocate the application of similar collaborative models in other complex health areas such as nanomedicine and biomedical engineering.
View Article and Find Full Text PDFPLoS One
January 2025
School of Business, Anyang Normal University, Anyang, China.
The process of regional economic development is marked by a sustained exposure to external disturbances. In today's unpredictable and tumultuous global environment, such disturbances have become increasingly common, underlining the need to advance a region's economic resilience and foster adaptive mechanisms to handle environmental flux. Comparing the typical provinces in eastern, central, western and northeastern regions during the COVID-19 epidemic period, it found that the economic resilience performance of Henan Province, which is a representative of the central region, has the following characteristics.
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