A 62-year-old female patient suffering from ST elevation myocardial infarction (STEMI) was transported to a cardiology facility. During transport, the monitor triggered an alarm for tachycardia despite a normal pulse. The reason was a misinterpretation of the ECG software, which double counted the QRS complex. QRS double counting has been reported in the setting of hyperkalemia only. In this case report, QRS double counting in association with STEMI is documented for the first time. Healthcare workers who are monitoring patients with myocardial infarction should be aware of this misdiagnosis and able to recognize the pattern.
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http://dx.doi.org/10.1007/s00399-023-00925-8 | DOI Listing |
Pflugers Arch
October 2024
Department of Histology - Embryology, Manisa Celal Bayar University, Manisa, Turkey.
Histamine H3 receptors (H3Rs) are known to modulate neurotransmitter release in the nervous system, but their role in cardiac injury remains unclear. The present study aimed to investigate the cardioprotective role of H3Rs in a mouse model of myocardial injury. Forty BALB/c male mice were divided into four groups: Control (SF), Isoproterenol (ISO), Imetit (IMT), and IMT + ISO.
View Article and Find Full Text PDFClin Pharmacol Drug Dev
November 2024
Clario, Philadelphia, PA, USA.
Vatiquinone, a 15-lipoxygenase inhibitor, is in development for patients with Friedreich ataxia. The study determined the effect of vatiquinone on electrocardiogram parameters. This was a 2-part, single-center, randomized, double-blinded, and placebo-controlled study.
View Article and Find Full Text PDFbioRxiv
August 2024
Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, IL 60637, USA.
The cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors and are required for cardiac conduction system development and associated with overlapping and distinct human cardiac conduction system diseases. We evaluated the coordinated role of and in the murine ventricular conduction system (VCS).
View Article and Find Full Text PDFEur J Heart Fail
October 2024
National Heart and Lung Institute, Imperial College London, London, UK.
Aims: The randomized, double-blind, placebo-controlled HOPE-HF trial assessed the benefit of atrio-ventricular (AV) delay optimization delivered using His bundle pacing. It recruited patients with left ventricular ejection fraction ≤40%, PR interval ≥200 ms, and baseline QRS ≤140 ms or right bundle branch block. Overall, there was no significant increase in peak oxygen uptake (VOmax) but there was significant improvement in heart failure specific quality of life.
View Article and Find Full Text PDFESC Heart Fail
December 2024
Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Aims: One third of patients do not improve after cardiac resynchronization therapy (CRT). Septal flash (SF) and apical rocking (ApRock) are deformation patterns observed on echocardiography in most patients eligible for CRT. These markers of mechanical dyssynchrony have been associated to improved outcome after CRT in observational studies and may be useful to better select patients.
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