AI Article Synopsis
- Understanding how organisms learn and store memories is a crucial area of research in neuroscience, focusing on the molecular and genetic pathways involved in memory acquisition and consolidation.
- C. elegans, a model organism, is particularly useful for exploring these processes due to its simple nervous system, fully mapped genome, and ability to display conserved learning behaviors.
- This mini-review highlights innovative genetic and genomic techniques that provide insights into the molecular mechanisms of memory, ranging from studies on the whole organism down to specific tissues and cell types.
Article Abstract
How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In this mini-review, we discuss novel and exciting genetic and genomic techniques used to examine molecular and genetic underpinnings of memory from the level of the whole-worm to tissue-specific and cell-type specific approaches with high spatiotemporal resolution.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518207 | PMC |
| http://dx.doi.org/10.1042/BST20220455 | DOI Listing |
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