AI Article Synopsis
- Liver disorders are a major global health issue, affecting over 1.5 billion people and involving various liver cell types like hepatocytes and Kupffer cells in disease progression.
- Researchers are investigating the role of factors like oxidative stress and microRNAs in liver diseases to better understand their molecular mechanisms.
- Recent advancements in treatments, such as antioxidant therapy, gene therapy, and the use of nanoparticles, show promise for preventing and managing liver disorders effectively.
Article Abstract
Liver disorders are one of the most common pathological problems worldwide. It affects more than 1.5 billion worldwide. Many types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chronic liver diseases, including hepatocytes, Kupffer cells, sinusoidal endothelial cells, and hepatic stellate cells (HSCs). In addition, oxidative stress, cytokines, fibrogenic factors, microRNAs, and autophagy are also involved. Understanding the molecular mechanisms of liver diseases leads to discovering new therapeutic interventions that can be used in clinics. Recently, antioxidant, anti-inflammatory, anti-HSCs therapy, gene therapy, cell therapy, gut microbiota, and nanoparticles have great potential for preventing and treating liver diseases. Here, we explored the recent possible molecular mechanisms involved in the pathogenesis of acute and chronic liver diseases. Besides, we overviewed the recent therapeutic interventions that targeted liver diseases and summarized the recent studies concerning liver disorders therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896501 | PMC |
| http://dx.doi.org/10.4254/wjh.v15.i1.19 | DOI Listing |
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