Background: Osteochondral autograft transfer (OAT) is a useful technique for full-thickness cartilage lesions of the distal femur. Various techniques recommend harvesting a plug 2 mm longer than the recipient hole to allow for graft impaction. Grafts with limited compressibility may not sit flush when impacted.
Purpose: To compare the compressibility/shortening of OAT donor plug regions from the distal femur of human cadaveric knees after impaction.
Study Design: Controlled laboratory study.
Methods: A total of 20 cadaveric knees (mean age, 70.3 ± 8.4 years) were divided into 4 donor regions: medial intercondylar (IC) notch, lateral IC notch, medial trochlea, and lateral trochlea. Each region was subdivided into 4 zones: far superior (FSZ), middle superior (MSZ), middle inferior (MIZ), and far inferior (FIZ). A total of 320 grafts (6-mm diameter, 15-mm depth) were extracted, and a custom-built machine was used to strike the graft 5 times using a predetermined energy of 0.11 J. The graft length was measured initially and after each impact. Statistical analysis of the compressibility for each of the 4 regions and all 16 zones was performed utilizing analysis of variance, with post hoc testing using the Fisher's least significant difference.
Results: Compression in the lateral IC notch, medial IC notch, medial trochlea, and lateral trochlea was 2.4 ± 1.5, 2.1 ± 0.7, 3.1 ± 2.2, and 2.1 ± 0.6 mm, respectively, with significant differences between the 4 regions ( < .01) and the most compression in the medial trochlea ( < .01). Subgroup analysis showed that the lateral trochlea had higher compressibility for FIZ versus MIZ ( = .02) and the lateral IC notch had higher compressibility for FSZ versus FIZ and MIZ ( < .05 for both).
Conclusion: Compressibility varied between OAT donor sites in the distal femur. OAT donor grafts showed the highest compressibility in the medial trochlea (3.1 mm) and lateral IC notch FSZ (3.0 mm).
Clinical Relevance: The lateral trochlea, medial IC notch, and the lower zones of the lateral IC notch grafts should not be oversized more than 2 mm in length, as these grafts may not compress adequately.
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http://dx.doi.org/10.1177/23259671221147329 | DOI Listing |
J Mech Behav Biomed Mater
December 2024
Aix Marseille Université, Université Gustave Eiffel, LBA, Marseille, France. Electronic address:
This study proposes a method for assessing the transverse toughness of human long-bone cortical tissue. The method is based on a three-point bending test of pre-notched femur diaphysis segments, post-processed using the compliance method coupled with numerical simulations. Given the cracking nature of bone and if cracking processes remain confined to the crack tip, it is assumed that the compliance method can be used.
View Article and Find Full Text PDFCartilage
December 2024
Department of Orthopaedic Surgery, LSU Health Shreveport, Shreveport, LA, USA.
Introduction: Distal femoral cartilage lesions can be treated using osteochondral autograft transfer (OAT). When impacting plugs into a recipient site, the cartilage may fracture. This study aimed to analyze OAT donor regions and impaction energies to identify characteristics that lead to fracture.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles CA 90033.
During tissue regeneration, lineage-related cells can switch their fate to replace missing cells. This cell plasticity is particularly prominent in more regenerative vertebrates such as zebrafish, yet the molecular basis by which cells transdifferentiate into another cell type upon injury remains unclear. Here, we investigate the epigenetic basis of regenerative transdifferentiation in the inner ear, where supporting cells (SCs) generate mechanosensory hair cells (HCs) upon damage.
View Article and Find Full Text PDFDent Med Probl
December 2024
Department of Social Sciences, School of Medicine, Qazvin University of Medical Sciences, Iran.
Background: The ability to predict the extent and direction of horizontal growth of the patient's face at an early age allows clinicians to timely identify cases that require treatment during the growth period and to ensure that appropriate treatment can be administered.
Objectives: The aim of this study was to investigate the role of the antegonial angle, gonial angle, antegonial notch depth, and the type of the antegonial notch on predicting horizontal facial growth in individuals with normal facial height.
Material And Methods: In this descriptive analytic study, lateral and panoramic radiographs of 180 patients aged 17-30 years with normal facial height who were referred to the School of Dentistry of Qazvin University of Medical Sciences and private dental clinics were investigated.
Curr Rev Musculoskelet Med
December 2024
Department of Orthopaedic Surgery, University of California San Francisco, 500 Parnassus Ave MU-320W, San Francisco, CA, 94143, USA.
Purpose Of The Review: There have been tremendous modifications to the humeral component since Paul Grammont first introduced the reverse total shoulder arthroplasty in 1985. The purpose of this article is to review historical design features and their drawbacks and to summarize the clinical outcomes of modern designs.
Recent Findings: Decreasing the neck-shaft angle and increasing humeral lateralization have helped address problems of scapular notching and limited internal and external rotation that were common with traditional designs.
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