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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895702 | PMC |
| http://dx.doi.org/10.1007/s12070-021-02782-8 | DOI Listing |
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Jigsaw as a Revision Module for Enhancing Learning in Biochemistry Among First-Year Medical Students.
Cureus
November 2024
Department of Biochemistry, All India Institute of Medical Sciences, Punjab, IND.
Aim Biochemistry includes the elaborate study of various biomolecules and intricate mechanisms that first-year medical students find difficult to understand and retain when taught through didactic lectures. Therefore, this study aims to test the effectiveness of jigsaw as a revision module in increasing the knowledge and retention capacity of students in Biochemistry. Materials and methods Eighty students were enrolled in the study.
View Article and Find Full Text PDFExosome-mediated delivery of CRISPR-Cas9: A revolutionary approach to cancer gene editing.
Pathol Res Pract
December 2024
Department of Biotechnology, Graphic Era (Deemed to be University), Clement Town, Dehradun 248002, India. Electronic address:
Several molecular strategies based on targeted gene delivery systems have been developed in recent years; however, the CRISPR-Cas9 technology introduced a new era of targeted gene editing, precisely modifying oncogenes, tumor suppressor genes, and other regulatory genes involved in carcinogenesis. However, efficiently and safely delivering CRISPR-Cas9 to cancer cells across the cell membrane and the nucleus is still challenging. Using viral vectors and nanoparticles presents issues of immunogenicity, off-target effects, and low targeting affinity.
View Article and Find Full Text PDFLiquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics.
Clin Chim Acta
December 2024
Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India. Electronic address:
Pancreatic cancer is a highly fatal malignancy due to poor early detection rate and resistance to conventional therapies. This review examines the potential for liquid biopsy as a transformative technology to identify diagnostic and therapeutic targets in pancreatic cancer. Specifically, we explore emerging biomarkers such as exosomal non-coding RNAs (ncRNAs), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs).
View Article and Find Full Text PDFCyclic di-AMP regulates genome stability and drug resistance in through RecA-dependent and RecA-independent recombination.
PNAS Nexus
December 2024
Amity Institute of Biotechnology, Amity University Haryana, Gurgaon, Haryana 122413, India.
In , RecA plays a central role in the rescue of stalled replication forks, double-strand break (DSB) repair, homologous recombination (HR), and induction of the SOS response. While the RecA-dependent pathway is dominant, alternative HR pathways that function independently of RecA do exist, but relatively little is known about the underlying mechanism. Several studies have documented that a variety of proteins act as either positive or negative regulators of RecA to ensure high-fidelity HR and genomic stability.
View Article and Find Full Text PDFBackground: Futibatinib is the only covalent inhibitor of FGFR1-4 to gain regulatory approval in oncology. Here, we present genomic analyses of tissue biopsies and circulating tumor DNA (ctDNA) from patients with one of nearly 20 tumor types treated with futibatinib in the phase I/II FOENIX study.
Patients And Methods: Eligible patients included those with ctDNA samples collected per protocol at baseline and/or progression on futibatinib in the phase Ib portion of the study for FGF/FGFR-altered advanced solid tumors or the phase II portion of the study for FGFR2 fusion/rearrangement-positive cholangiocarcinoma.
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